Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cogniti...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/4318475 |
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| _version_ | 1832556763133509632 |
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| author | Blake J. Lawrence Natalie Gasson Andrew R. Johnson Leon Booth Andrea M. Loftus |
| author_facet | Blake J. Lawrence Natalie Gasson Andrew R. Johnson Leon Booth Andrea M. Loftus |
| author_sort | Blake J. Lawrence |
| collection | DOAJ |
| description | This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75). More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS. Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects. |
| format | Article |
| id | doaj-art-91b3601c1bb046b4b7010486bd36023f |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-91b3601c1bb046b4b7010486bd36023f2025-02-03T05:44:25ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/43184754318475Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled TrialBlake J. Lawrence0Natalie Gasson1Andrew R. Johnson2Leon Booth3Andrea M. Loftus4Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Bentley, WA 6102, AustraliaCurtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Bentley, WA 6102, AustraliaCurtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Bentley, WA 6102, AustraliaCurtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Bentley, WA 6102, AustraliaCurtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Bentley, WA 6102, AustraliaThis study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75). More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS. Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects.http://dx.doi.org/10.1155/2018/4318475 |
| spellingShingle | Blake J. Lawrence Natalie Gasson Andrew R. Johnson Leon Booth Andrea M. Loftus Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial Parkinson's Disease |
| title | Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial |
| title_full | Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial |
| title_fullStr | Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial |
| title_full_unstemmed | Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial |
| title_short | Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial |
| title_sort | cognitive training and transcranial direct current stimulation for mild cognitive impairment in parkinson s disease a randomized controlled trial |
| url | http://dx.doi.org/10.1155/2018/4318475 |
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