A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan
<b>Background and Objectives:</b> The study aimed at identification and analysis of adverse COVID-19 outcomes (admission to intensive care units due to COVID-19, acute respiratory distress syndrome, mechanical ventilation, and death) among hospitalized pregnant and nonpregnant women, whi...
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2025-04-01
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| author | Zhansaya Nurgaliyeva Lyudmila Pivina Sharapat Moiynbayeva Galiya Alibayeva Meruyert Suleimenova Nailya Kozhekenova Moldir Abdullina Maulen Malgazhdarov Mira Turbekova Dejan Nikolic Milan Lackovic Antonio Sarria-Santamera Milena Santric-Milicevic |
| author_facet | Zhansaya Nurgaliyeva Lyudmila Pivina Sharapat Moiynbayeva Galiya Alibayeva Meruyert Suleimenova Nailya Kozhekenova Moldir Abdullina Maulen Malgazhdarov Mira Turbekova Dejan Nikolic Milan Lackovic Antonio Sarria-Santamera Milena Santric-Milicevic |
| author_sort | Zhansaya Nurgaliyeva |
| collection | DOAJ |
| description | <b>Background and Objectives:</b> The study aimed at identification and analysis of adverse COVID-19 outcomes (admission to intensive care units due to COVID-19, acute respiratory distress syndrome, mechanical ventilation, and death) among hospitalized pregnant and nonpregnant women, which are critical for informed decision-making in obstetric diagnostics and healthcare. <b>Materials and Methods:</b> This was a retrospective observational study conducted on a series of inpatient pregnant women comparatively followed up with nonpregnant women hospitalized between 15 July 2020 to 20 January 2022 across multidisciplinary hospitals in three cities of Kazakhstan. Following group matching with propensity score for COVID-19 disease severity, residence status, and age, the study ultimately included 156 participants, of whom 50% were pregnant, from an initial sample of 314 female inpatients diagnosed with COVID-19. All findings were considered statistically significant at a <i>p</i>-value < 0.05. <b>Results:</b> Laboratory investigations revealed significantly elevated levels of erythrocyte sedimentation rate, creatinine, neutrophils, platelet count, alanine aminotransferase, aspartate aminotransferase, lymphocyte count, and C-reactive protein in pregnant inpatients compared to nonpregnant inpatients. Furthermore, pregnant women exhibited significantly higher levels of D-dimer (2402.97 ng/mL vs. 793.91 ng/mL) and procalcitonin (0.398 ng/mL vs. 0.134 ng/mL) compared to their nonpregnant counterparts. Overall, 16.88% of the pregnant women were admitted to the intensive care unit, whereas among the nonpregnant women, only 2.6% were hospitalized. The most lethal outcomes (8.3%) occurred among pregnant women, while for nonpregnant women, there were two cases (1.3%). <b>Conclusions:</b> Pregnant women diagnosed with COVID-19 may exhibit more severe clinical symptoms and encounter more adverse outcomes compared to their nonpregnant counterparts. Future research should incorporate larger matched samples to comprehensively explore the association between additional factors and clinical conditions. |
| format | Article |
| id | doaj-art-91a953a3e05248b788aecd1deabba1b2 |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-91a953a3e05248b788aecd1deabba1b22025-08-20T03:08:47ZengMDPI AGDiagnostics2075-44182025-04-0115790010.3390/diagnostics15070900A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of KazakhstanZhansaya Nurgaliyeva0Lyudmila Pivina1Sharapat Moiynbayeva2Galiya Alibayeva3Meruyert Suleimenova4Nailya Kozhekenova5Moldir Abdullina6Maulen Malgazhdarov7Mira Turbekova8Dejan Nikolic9Milan Lackovic10Antonio Sarria-Santamera11Milena Santric-Milicevic12Faculty of Medicine and Health Care, Al-Farabi Kazakh National University, Almaty 050044, KazakhstanDepartment of Internal Medicine, Semey Medical University, Semey 071407, KazakhstanDepartment of Science and Consulting, Kazakhstan Medical University «KSPH», Almaty 050044, KazakhstanSemey Emergency Hospital, Semey 071407, KazakhstanDepartment of Science, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050044, KazakhstanFaculty of Medicine and Health Care, Al-Farabi Kazakh National University, Almaty 050044, KazakhstanFaculty of Medicine and Health Care, Al-Farabi Kazakh National University, Almaty 050044, KazakhstanDepartment of Surgical Diseases No. 2, Kazakh-Russian Medical University, Almaty 050044, KazakhstanDepartment of Clinical Disciplines, Al-Farabi Kazakh National University, Almaty 050044, KazakhstanFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaUniversity Hospital “Dragisa Misovic”, 11000 Belgrade, SerbiaSchool of Medicine, Nazarbayev University, Astana 010000, KazakhstanFaculty of Medicine and Health Care, Al-Farabi Kazakh National University, Almaty 050044, Kazakhstan<b>Background and Objectives:</b> The study aimed at identification and analysis of adverse COVID-19 outcomes (admission to intensive care units due to COVID-19, acute respiratory distress syndrome, mechanical ventilation, and death) among hospitalized pregnant and nonpregnant women, which are critical for informed decision-making in obstetric diagnostics and healthcare. <b>Materials and Methods:</b> This was a retrospective observational study conducted on a series of inpatient pregnant women comparatively followed up with nonpregnant women hospitalized between 15 July 2020 to 20 January 2022 across multidisciplinary hospitals in three cities of Kazakhstan. Following group matching with propensity score for COVID-19 disease severity, residence status, and age, the study ultimately included 156 participants, of whom 50% were pregnant, from an initial sample of 314 female inpatients diagnosed with COVID-19. All findings were considered statistically significant at a <i>p</i>-value < 0.05. <b>Results:</b> Laboratory investigations revealed significantly elevated levels of erythrocyte sedimentation rate, creatinine, neutrophils, platelet count, alanine aminotransferase, aspartate aminotransferase, lymphocyte count, and C-reactive protein in pregnant inpatients compared to nonpregnant inpatients. Furthermore, pregnant women exhibited significantly higher levels of D-dimer (2402.97 ng/mL vs. 793.91 ng/mL) and procalcitonin (0.398 ng/mL vs. 0.134 ng/mL) compared to their nonpregnant counterparts. Overall, 16.88% of the pregnant women were admitted to the intensive care unit, whereas among the nonpregnant women, only 2.6% were hospitalized. The most lethal outcomes (8.3%) occurred among pregnant women, while for nonpregnant women, there were two cases (1.3%). <b>Conclusions:</b> Pregnant women diagnosed with COVID-19 may exhibit more severe clinical symptoms and encounter more adverse outcomes compared to their nonpregnant counterparts. Future research should incorporate larger matched samples to comprehensively explore the association between additional factors and clinical conditions.https://www.mdpi.com/2075-4418/15/7/900pregnancyCOVID-19severityadverse outcomespropensity score matchinginpatient care |
| spellingShingle | Zhansaya Nurgaliyeva Lyudmila Pivina Sharapat Moiynbayeva Galiya Alibayeva Meruyert Suleimenova Nailya Kozhekenova Moldir Abdullina Maulen Malgazhdarov Mira Turbekova Dejan Nikolic Milan Lackovic Antonio Sarria-Santamera Milena Santric-Milicevic A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan Diagnostics pregnancy COVID-19 severity adverse outcomes propensity score matching inpatient care |
| title | A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan |
| title_full | A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan |
| title_fullStr | A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan |
| title_full_unstemmed | A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan |
| title_short | A Multicentric Study on Adverse COVID-19 Outcomes Among Pregnant and Nonpregnant Women in Multidisciplinary Hospitals of Kazakhstan |
| title_sort | multicentric study on adverse covid 19 outcomes among pregnant and nonpregnant women in multidisciplinary hospitals of kazakhstan |
| topic | pregnancy COVID-19 severity adverse outcomes propensity score matching inpatient care |
| url | https://www.mdpi.com/2075-4418/15/7/900 |
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