Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis
Objectives. Sepsis is characterized as a dysregulated host immune response to infection and has been known to be closely associated with the gut microbiome. This study was aimed at investigating the gut microbial profiles of Zhuang ethnic patients with sepsis. Method. Eleven Zhuang ethnic patients w...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/2808249 |
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| author | Jieyang Yu Hongping Li Jingjie Zhao Yanhua Huang Chunlei Liu Pengfei Yang Dinggui Lu Jian Song Lingzhang Meng |
| author_facet | Jieyang Yu Hongping Li Jingjie Zhao Yanhua Huang Chunlei Liu Pengfei Yang Dinggui Lu Jian Song Lingzhang Meng |
| author_sort | Jieyang Yu |
| collection | DOAJ |
| description | Objectives. Sepsis is characterized as a dysregulated host immune response to infection and has been known to be closely associated with the gut microbiome. This study was aimed at investigating the gut microbial profiles of Zhuang ethnic patients with sepsis. Method. Eleven Zhuang ethnic patients with sepsis and 20 healthy individuals (controls) were recruited at the Baise City People’s Hospital, China. Their gut microbial community profiles were analyzed by 16S rRNA gene sequencing using the Illumina MiSeq system. Results. The gut microbial community of patients with sepsis was significantly altered compared to that of the healthy individuals based on the results of principal coordinate analysis and microbial ecological networks. Additionally, significantly lower microbial alpha diversity was observed in patients with sepsis than in healthy individuals. In particular, the enrichment of Bilophila, Burkholderia, Corynebacterium, and Porphyromonas, along with the reduced abundance of a large number of short-chain fatty acid-producing microbes, including Roseburia, Bifidobacterium, Faecalibacterium, Coprococcus, Blautia, Clostridium, Ruminococcus, and Anaerostipe was observed in patients with sepsis compared to the control group. Moreover, patients with sepsis could be effectively classified based on the abundance of these bacteria using a support vector machine algorithm. Conclusion. This study demonstrated significant differences in the gut microbiome between Zhuang ethnic patients with sepsis and healthy individuals. In the future, it is necessary to determine whether such alterations are the cause or consequence of sepsis. |
| format | Article |
| id | doaj-art-91a81b6ec504459fbba28d8cab1f4ec3 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-91a81b6ec504459fbba28d8cab1f4ec32025-02-03T01:06:35ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/2808249Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with SepsisJieyang Yu0Hongping Li1Jingjie Zhao2Yanhua Huang3Chunlei Liu4Pengfei Yang5Dinggui Lu6Jian Song7Lingzhang Meng8Center for Systemic Inflammation Research (CSIR)Neonatal Intensive Care UnitLife Science and Clinical Research CenterDepartment of Critical Care MedicineBaise Maternal and Child HospitalBaise Maternal and Child HospitalTrauma CenterCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Objectives. Sepsis is characterized as a dysregulated host immune response to infection and has been known to be closely associated with the gut microbiome. This study was aimed at investigating the gut microbial profiles of Zhuang ethnic patients with sepsis. Method. Eleven Zhuang ethnic patients with sepsis and 20 healthy individuals (controls) were recruited at the Baise City People’s Hospital, China. Their gut microbial community profiles were analyzed by 16S rRNA gene sequencing using the Illumina MiSeq system. Results. The gut microbial community of patients with sepsis was significantly altered compared to that of the healthy individuals based on the results of principal coordinate analysis and microbial ecological networks. Additionally, significantly lower microbial alpha diversity was observed in patients with sepsis than in healthy individuals. In particular, the enrichment of Bilophila, Burkholderia, Corynebacterium, and Porphyromonas, along with the reduced abundance of a large number of short-chain fatty acid-producing microbes, including Roseburia, Bifidobacterium, Faecalibacterium, Coprococcus, Blautia, Clostridium, Ruminococcus, and Anaerostipe was observed in patients with sepsis compared to the control group. Moreover, patients with sepsis could be effectively classified based on the abundance of these bacteria using a support vector machine algorithm. Conclusion. This study demonstrated significant differences in the gut microbiome between Zhuang ethnic patients with sepsis and healthy individuals. In the future, it is necessary to determine whether such alterations are the cause or consequence of sepsis.http://dx.doi.org/10.1155/2022/2808249 |
| spellingShingle | Jieyang Yu Hongping Li Jingjie Zhao Yanhua Huang Chunlei Liu Pengfei Yang Dinggui Lu Jian Song Lingzhang Meng Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis Mediators of Inflammation |
| title | Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis |
| title_full | Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis |
| title_fullStr | Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis |
| title_full_unstemmed | Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis |
| title_short | Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis |
| title_sort | alterations of the gut microbiome in chinese zhuang ethnic patients with sepsis |
| url | http://dx.doi.org/10.1155/2022/2808249 |
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