Genomic and transcriptomic insights into vertebrate host-specific Lactobacillus johnsonii adaptation in the gastrointestinal tract

Genomic and transcriptomic insights into vertebrate host-specific Lactobacillus johnsonii adaptation in the gastrointestinal tract

ABSTRACT We conducted a comparative genomic analysis of Lactobacillus johnsonii strains isolated from the gastrointestinal tract of diverse vertebrate hosts to explore the genetic basis of host specificity. We then utilized transcriptomics analysis to investigate the expression profile of identified...

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Bibliographic Details
Main Authors: Keerthikka Ravi, Nicole R. Falkowski, Gary B. Huffnagle
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mSphere
Subjects:
lactic acid bacteria
host-specific genes
tyrosine decarboxylase
accessory secretory pathway
strain heterogeneity
pangenome
Online Access:https://journals.asm.org/doi/10.1128/msphere.00052-25
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