Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid

Diffractic acid 1 is a secondary metabolite of depside lichens with antibacterial and insecticidal properties, and anticancer, hepatoprotective and antiviral activities. Novel diffractaic acid derivatives containing a 1,2,4-oxadiazole ring with an aryl substituent have been synthesized by the reacti...

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Main Authors: Aleksandr Filimonov, Anastasia Diveikina, Yuri Gatilov, Olga Luzina, Nariman Salakhutdinov
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molbank
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Online Access:https://www.mdpi.com/1422-8599/2024/4/M1912
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author Aleksandr Filimonov
Anastasia Diveikina
Yuri Gatilov
Olga Luzina
Nariman Salakhutdinov
author_facet Aleksandr Filimonov
Anastasia Diveikina
Yuri Gatilov
Olga Luzina
Nariman Salakhutdinov
author_sort Aleksandr Filimonov
collection DOAJ
description Diffractic acid 1 is a secondary metabolite of depside lichens with antibacterial and insecticidal properties, and anticancer, hepatoprotective and antiviral activities. Novel diffractaic acid derivatives containing a 1,2,4-oxadiazole ring with an aryl substituent have been synthesized by the reaction of diffractaic acid with amidoximes.
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id doaj-art-919dacc3eae144e3a320a1b48cab4f92
institution DOAJ
issn 1422-8599
language English
publishDate 2024-11-01
publisher MDPI AG
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spelling doaj-art-919dacc3eae144e3a320a1b48cab4f922025-08-20T02:56:52ZengMDPI AGMolbank1422-85992024-11-0120244M191210.3390/M1912Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic AcidAleksandr Filimonov0Anastasia Diveikina1Yuri Gatilov2Olga Luzina3Nariman Salakhutdinov4N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Lavrentieva Ave., 630090 Novosibirsk, RussiaDiffractic acid 1 is a secondary metabolite of depside lichens with antibacterial and insecticidal properties, and anticancer, hepatoprotective and antiviral activities. Novel diffractaic acid derivatives containing a 1,2,4-oxadiazole ring with an aryl substituent have been synthesized by the reaction of diffractaic acid with amidoximes.https://www.mdpi.com/1422-8599/2024/4/M1912diffractaic aciddepsidelichen metabolite1,2,4-oxadiazoles
spellingShingle Aleksandr Filimonov
Anastasia Diveikina
Yuri Gatilov
Olga Luzina
Nariman Salakhutdinov
Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
Molbank
diffractaic acid
depside
lichen metabolite
1,2,4-oxadiazoles
title Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
title_full Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
title_fullStr Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
title_full_unstemmed Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
title_short Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
title_sort synthesis of 1 2 4 oxadiazoles based on diffractaic acid
topic diffractaic acid
depside
lichen metabolite
1,2,4-oxadiazoles
url https://www.mdpi.com/1422-8599/2024/4/M1912
work_keys_str_mv AT aleksandrfilimonov synthesisof124oxadiazolesbasedondiffractaicacid
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AT yurigatilov synthesisof124oxadiazolesbasedondiffractaicacid
AT olgaluzina synthesisof124oxadiazolesbasedondiffractaicacid
AT narimansalakhutdinov synthesisof124oxadiazolesbasedondiffractaicacid