Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae)
The bio-prospecting of bioactive phytochemicals from invasive flora presents a sustainable paradigm for the ecologically conscious management of major invasive pest <i>S. invicta</i>. <i>Ageratina adenophora</i>, while recognized for its allelopathic insecticidal properties,...
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2025-05-01
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| author | Mingqi Wu Rongchao Luo Mehboob Hussain Wenmei Wu Shini Li Zijun Guo Boyu Jia Gaofeng Bi Xi Gao Guoxing Wu Deqiang Qin |
| author_facet | Mingqi Wu Rongchao Luo Mehboob Hussain Wenmei Wu Shini Li Zijun Guo Boyu Jia Gaofeng Bi Xi Gao Guoxing Wu Deqiang Qin |
| author_sort | Mingqi Wu |
| collection | DOAJ |
| description | The bio-prospecting of bioactive phytochemicals from invasive flora presents a sustainable paradigm for the ecologically conscious management of major invasive pest <i>S. invicta</i>. <i>Ageratina adenophora</i>, while recognized for its allelopathic insecticidal properties, exhibits poorly characterized toxicological profiles and mechanistic underpinnings against <i>S. invicta</i>, warranting systematic investigation to elucidate its mode of action. This study elucidates the bioactive insecticidal compounds of <i>A. adenophora</i> and their toxicological impacts on <i>S. invicta</i>, including behavioral, metabolic, and enzymatic perturbations, via liquid chromatography–mass spectrometry (LC-MS) profiling. The ethanol extracts of the roots, stems, and leaves of <i>A. adenophora</i> have shown control effects on <i>S. invicta</i>, with an LC<sub>50</sub> (50% lethal concentration) of 331.847, 188.256, and 166.253 mg/mL at 48 h, respectively. Metabolite profiling of <i>A. adenophora</i> revealed that safranal and dihydrocoumarin are relatively high in plant leaves, and they showed significant insecticidal activity and behavioral inhibitory effects on <i>S. invicta</i> with LC<sub>50</sub> 349.042 mg/L and 118.336 mg/L at 48 h, respectively. Notably, these two bioactive compounds disrupted the normal energy production through glucose metabolism and the citrate cycle, which eventually led to the death of <i>S. invicta</i>. Further, these two compounds also activated the detoxification metabolic pathway of <i>S. invicta</i>. These findings provide a theoretical basis for the use of these bioactive compounds in the integrated management of <i>S. invicta</i> and may lead to the development of a new biopesticide. |
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| institution | OA Journals |
| issn | 2075-4450 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Insects |
| spelling | doaj-art-91985a0372e04db38a3b3afc68efd01a2025-08-20T01:56:16ZengMDPI AGInsects2075-44502025-05-0116554010.3390/insects16050540Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae)Mingqi Wu0Rongchao Luo1Mehboob Hussain2Wenmei Wu3Shini Li4Zijun Guo5Boyu Jia6Gaofeng Bi7Xi Gao8Guoxing Wu9Deqiang Qin10State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaSchool of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, ChinaThe bio-prospecting of bioactive phytochemicals from invasive flora presents a sustainable paradigm for the ecologically conscious management of major invasive pest <i>S. invicta</i>. <i>Ageratina adenophora</i>, while recognized for its allelopathic insecticidal properties, exhibits poorly characterized toxicological profiles and mechanistic underpinnings against <i>S. invicta</i>, warranting systematic investigation to elucidate its mode of action. This study elucidates the bioactive insecticidal compounds of <i>A. adenophora</i> and their toxicological impacts on <i>S. invicta</i>, including behavioral, metabolic, and enzymatic perturbations, via liquid chromatography–mass spectrometry (LC-MS) profiling. The ethanol extracts of the roots, stems, and leaves of <i>A. adenophora</i> have shown control effects on <i>S. invicta</i>, with an LC<sub>50</sub> (50% lethal concentration) of 331.847, 188.256, and 166.253 mg/mL at 48 h, respectively. Metabolite profiling of <i>A. adenophora</i> revealed that safranal and dihydrocoumarin are relatively high in plant leaves, and they showed significant insecticidal activity and behavioral inhibitory effects on <i>S. invicta</i> with LC<sub>50</sub> 349.042 mg/L and 118.336 mg/L at 48 h, respectively. Notably, these two bioactive compounds disrupted the normal energy production through glucose metabolism and the citrate cycle, which eventually led to the death of <i>S. invicta</i>. Further, these two compounds also activated the detoxification metabolic pathway of <i>S. invicta</i>. These findings provide a theoretical basis for the use of these bioactive compounds in the integrated management of <i>S. invicta</i> and may lead to the development of a new biopesticide.https://www.mdpi.com/2075-4450/16/5/540<i>Solenopsis invicta</i><i>Ageratina adenophora</i>toxicityinsecticidal mechanismsecondary metabolites |
| spellingShingle | Mingqi Wu Rongchao Luo Mehboob Hussain Wenmei Wu Shini Li Zijun Guo Boyu Jia Gaofeng Bi Xi Gao Guoxing Wu Deqiang Qin Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae) Insects <i>Solenopsis invicta</i> <i>Ageratina adenophora</i> toxicity insecticidal mechanism secondary metabolites |
| title | Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae) |
| title_full | Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae) |
| title_fullStr | Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae) |
| title_full_unstemmed | Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae) |
| title_short | Nature-Identical Safranal and Dihydrocoumarin from <i>Ageratina adenophora</i> ((Spreng., 1970) King and H. Rob.) Target Energy Metabolism to Control <i>Solenopsis invicta</i> Buren, 1972 (Hymenoptera: Formicidae) |
| title_sort | nature identical safranal and dihydrocoumarin from i ageratina adenophora i spreng 1970 king and h rob target energy metabolism to control i solenopsis invicta i buren 1972 hymenoptera formicidae |
| topic | <i>Solenopsis invicta</i> <i>Ageratina adenophora</i> toxicity insecticidal mechanism secondary metabolites |
| url | https://www.mdpi.com/2075-4450/16/5/540 |
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