Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects
Background/Objectives: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our...
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MDPI AG
2024-10-01
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| Online Access: | https://www.mdpi.com/2227-9059/12/10/2296 |
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| author | Guillermo Efrén Villar-Juárez Alma Delia Genis-Mendoza J. Nicolas I. Martínez-López Ana Fresan Carlos Alfonso Tovilla-Zaráte German Alberto Nolasco-Rosales Ghandy Isidro Juárez-De la Cruz David Ruiz Ramos Mario Villar-Soto Paola Mejía-Ortiz Marlen Gómez Mendiola Isela Esther Juárez-Rojop Humberto Nicolini |
| author_facet | Guillermo Efrén Villar-Juárez Alma Delia Genis-Mendoza J. Nicolas I. Martínez-López Ana Fresan Carlos Alfonso Tovilla-Zaráte German Alberto Nolasco-Rosales Ghandy Isidro Juárez-De la Cruz David Ruiz Ramos Mario Villar-Soto Paola Mejía-Ortiz Marlen Gómez Mendiola Isela Esther Juárez-Rojop Humberto Nicolini |
| author_sort | Guillermo Efrén Villar-Juárez |
| collection | DOAJ |
| description | Background/Objectives: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation between telomere length and cognitive changes in post-COVID-19 subjects. Methods: This study included 256 subjects, categorized based on SARS-CoV-2 infection from 2020 to 2023. In addition, subjects with a psychiatric diagnosis were considered. Moreover, the MoCA and MMSE scales were applied. Telomere length was determined using a polymerase chain reaction, and statistical analysis was employed using ANOVA and X<sup>2</sup> tests. Results: We identified a decrease in LTL in individuals with post-COVID-19 conditions compared to those without SARS-CoV-2 infection (<i>p</i> ≤ 0.05). However, no association was found between LTL and cognitive impairment in the subjects post-COVID-19. Conclusions: The findings suggest that LTL is affected by SARS-CoV-2 infection. Nonetheless, this important finding requires further research by monitoring neurological changes in subjects with post-COVID condition. |
| format | Article |
| id | doaj-art-91968e3ed7cc4ce096199467e275545e |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-91968e3ed7cc4ce096199467e275545e2025-08-20T02:11:09ZengMDPI AGBiomedicines2227-90592024-10-011210229610.3390/biomedicines12102296Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 SubjectsGuillermo Efrén Villar-Juárez0Alma Delia Genis-Mendoza1J. Nicolas I. Martínez-López2Ana Fresan3Carlos Alfonso Tovilla-Zaráte4German Alberto Nolasco-Rosales5Ghandy Isidro Juárez-De la Cruz6David Ruiz Ramos7Mario Villar-Soto8Paola Mejía-Ortiz9Marlen Gómez Mendiola10Isela Esther Juárez-Rojop11Humberto Nicolini12Escuela de Medicina, Universidad Anáhuac Querétaro, Querétaro 76246, MexicoInstituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City 14610, MexicoInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, MexicoInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, MexicoDivisón Académica Multidisciplinaria de Comalcalco, Universidad Juarez Autónoma de Tabasco, Comalcalco 86658, MexicoDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de Tabasco, Villahermosa 86100, MexicoDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de Tabasco, Villahermosa 86100, MexicoDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de Tabasco, Villahermosa 86100, MexicoHospital Regional de Alta Especialidad de Salud Mental, Villahermosa 86029, MexicoInstituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City 14610, MexicoHospital Psiquiátrico Infantil Dr. Juan N. Navarro, Servicios de Atención Psiquiátrica, Mexico City 14080, MexicoDivisión Académica de Ciencias de la Salud, Universidad Juarez Autónoma de Tabasco, Villahermosa 86100, MexicoInstituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City 14610, MexicoBackground/Objectives: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation between telomere length and cognitive changes in post-COVID-19 subjects. Methods: This study included 256 subjects, categorized based on SARS-CoV-2 infection from 2020 to 2023. In addition, subjects with a psychiatric diagnosis were considered. Moreover, the MoCA and MMSE scales were applied. Telomere length was determined using a polymerase chain reaction, and statistical analysis was employed using ANOVA and X<sup>2</sup> tests. Results: We identified a decrease in LTL in individuals with post-COVID-19 conditions compared to those without SARS-CoV-2 infection (<i>p</i> ≤ 0.05). However, no association was found between LTL and cognitive impairment in the subjects post-COVID-19. Conclusions: The findings suggest that LTL is affected by SARS-CoV-2 infection. Nonetheless, this important finding requires further research by monitoring neurological changes in subjects with post-COVID condition.https://www.mdpi.com/2227-9059/12/10/2296telomere lengthcognitive changespost-COVID-19SARS-CoV-2 |
| spellingShingle | Guillermo Efrén Villar-Juárez Alma Delia Genis-Mendoza J. Nicolas I. Martínez-López Ana Fresan Carlos Alfonso Tovilla-Zaráte German Alberto Nolasco-Rosales Ghandy Isidro Juárez-De la Cruz David Ruiz Ramos Mario Villar-Soto Paola Mejía-Ortiz Marlen Gómez Mendiola Isela Esther Juárez-Rojop Humberto Nicolini Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects Biomedicines telomere length cognitive changes post-COVID-19 SARS-CoV-2 |
| title | Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects |
| title_full | Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects |
| title_fullStr | Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects |
| title_full_unstemmed | Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects |
| title_short | Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects |
| title_sort | exploring the relationship between telomere length and cognitive changes in post covid 19 subjects |
| topic | telomere length cognitive changes post-COVID-19 SARS-CoV-2 |
| url | https://www.mdpi.com/2227-9059/12/10/2296 |
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