Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses
Since its discovery in 1992, the receptor for advanced glycation end products (RAGE) has emerged as a key receptor in many pathological conditions, especially in inflammatory conditions. RAGE is expressed by most, if not all, immune cells and can be activated by many ligands. One characteristic of R...
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MDPI AG
2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/12/1550 |
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| author | Kaylen Cross Stefan W. Vetter Yousuf Alam Md. Zahidul Hasan Anupom Deb Nath Estelle Leclerc |
| author_facet | Kaylen Cross Stefan W. Vetter Yousuf Alam Md. Zahidul Hasan Anupom Deb Nath Estelle Leclerc |
| author_sort | Kaylen Cross |
| collection | DOAJ |
| description | Since its discovery in 1992, the receptor for advanced glycation end products (RAGE) has emerged as a key receptor in many pathological conditions, especially in inflammatory conditions. RAGE is expressed by most, if not all, immune cells and can be activated by many ligands. One characteristic of RAGE is that its ligands are structurally very diverse and belong to different classes of molecules, making RAGE a promiscuous receptor. Many of RAGE ligands are damaged associated molecular patterns (DAMPs) that are released by cells under inflammatory conditions. Although RAGE has been at the center of a lot of research in the past three decades, a clear understanding of the mechanisms of RAGE activation by its ligands is still missing. In this review, we summarize the current knowledge of the role of RAGE and its ligands in inflammation. |
| format | Article |
| id | doaj-art-91927ab916684a2396fcc2568fc94147 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-91927ab916684a2396fcc2568fc941472025-08-20T02:01:04ZengMDPI AGBiomolecules2218-273X2024-12-011412155010.3390/biom14121550Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory ResponsesKaylen Cross0Stefan W. Vetter1Yousuf Alam2Md. Zahidul Hasan3Anupom Deb Nath4Estelle Leclerc5Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USADepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USADepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USADepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USADepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USADepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USASince its discovery in 1992, the receptor for advanced glycation end products (RAGE) has emerged as a key receptor in many pathological conditions, especially in inflammatory conditions. RAGE is expressed by most, if not all, immune cells and can be activated by many ligands. One characteristic of RAGE is that its ligands are structurally very diverse and belong to different classes of molecules, making RAGE a promiscuous receptor. Many of RAGE ligands are damaged associated molecular patterns (DAMPs) that are released by cells under inflammatory conditions. Although RAGE has been at the center of a lot of research in the past three decades, a clear understanding of the mechanisms of RAGE activation by its ligands is still missing. In this review, we summarize the current knowledge of the role of RAGE and its ligands in inflammation.https://www.mdpi.com/2218-273X/14/12/1550RAGEinflammationS100DAMPstress |
| spellingShingle | Kaylen Cross Stefan W. Vetter Yousuf Alam Md. Zahidul Hasan Anupom Deb Nath Estelle Leclerc Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses Biomolecules RAGE inflammation S100 DAMP stress |
| title | Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses |
| title_full | Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses |
| title_fullStr | Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses |
| title_full_unstemmed | Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses |
| title_short | Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses |
| title_sort | role of the receptor for advanced glycation end products rage and its ligands in inflammatory responses |
| topic | RAGE inflammation S100 DAMP stress |
| url | https://www.mdpi.com/2218-273X/14/12/1550 |
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