Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study
Background Polyamines have been reported to be associated with neurological function, but the associations between polyamines and the prognosis of ischemic stroke remain unclear. We aimed to prospectively investigate whether elevated plasma polyamine levels are associated with adverse outcomes in pa...
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Wiley
2024-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.035837 |
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| author | Pinni Yang Mengyao Shi Yiming Jia Chongke Zhong Hao Peng Lulu Sun Daoxia Guo Jing Chen Aili Wang Tan Xu Zhengbao Zhu Yonghong Zhang Jiang He |
| author_facet | Pinni Yang Mengyao Shi Yiming Jia Chongke Zhong Hao Peng Lulu Sun Daoxia Guo Jing Chen Aili Wang Tan Xu Zhengbao Zhu Yonghong Zhang Jiang He |
| author_sort | Pinni Yang |
| collection | DOAJ |
| description | Background Polyamines have been reported to be associated with neurological function, but the associations between polyamines and the prognosis of ischemic stroke remain unclear. We aimed to prospectively investigate whether elevated plasma polyamine levels are associated with adverse outcomes in patients with ischemic stroke. Methods and Results Plasma polyamine levels were measured at admission in 3570 patients with acute ischemic stroke, and clinical outcomes were assessed at 3 months after stroke onset. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale score≥3), and secondary outcomes included the individual outcomes of death and major disability. During a 3‐month follow‐up period, 877 participants (25.1%) experienced the primary outcome. Increased putrescines were associated with a decreased risk of the primary outcome (the highest versus the lowest tertile: odds ratio, 0.72 [95% CI, 0.58–0.91]; P=0.005) and major disability (odds ratio, 0.59 [95% CI, 0.47–0.74]; P<0.001). Conversely, increased spermidines were associated with an increased risk of death (hazard ratio, 1.86 [95% CI, 1.10–3.14]; P=0.020), and increased spermines were associated with an increased risk of the primary outcome (odds ratio, 1.36 [95% CI, 1.08–1.71]; P=0.009) and major disability (odds ratio, 1.27 [95% CI, 1.01–1.59]; P=0.041). Conclusions Among patients with ischemic stroke, high plasma putrescine levels were associated with a decreased risk of adverse outcomes, whereas high plasma spermidine and spermine levels were associated with an increased risk of adverse outcomes. Further studies are needed to investigate whether targeting these polyamines can improve the prognosis of patients with ischemic stroke. Registration https://clinicaltrials.gov. Identifier: NCT01840072. |
| format | Article |
| id | doaj-art-91924aa8d2cc41afb7c32778dd044651 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-91924aa8d2cc41afb7c32778dd0446512025-08-20T02:11:42ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-08-01131510.1161/JAHA.124.035837Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort StudyPinni Yang0Mengyao Shi1Yiming Jia2Chongke Zhong3Hao Peng4Lulu Sun5Daoxia Guo6Jing Chen7Aili Wang8Tan Xu9Zhengbao Zhu10Yonghong Zhang11Jiang He12Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaSchool of Nursing Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA USADepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non‐communicable Diseases Suzhou Medical College of Soochow University Suzhou ChinaDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA USABackground Polyamines have been reported to be associated with neurological function, but the associations between polyamines and the prognosis of ischemic stroke remain unclear. We aimed to prospectively investigate whether elevated plasma polyamine levels are associated with adverse outcomes in patients with ischemic stroke. Methods and Results Plasma polyamine levels were measured at admission in 3570 patients with acute ischemic stroke, and clinical outcomes were assessed at 3 months after stroke onset. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale score≥3), and secondary outcomes included the individual outcomes of death and major disability. During a 3‐month follow‐up period, 877 participants (25.1%) experienced the primary outcome. Increased putrescines were associated with a decreased risk of the primary outcome (the highest versus the lowest tertile: odds ratio, 0.72 [95% CI, 0.58–0.91]; P=0.005) and major disability (odds ratio, 0.59 [95% CI, 0.47–0.74]; P<0.001). Conversely, increased spermidines were associated with an increased risk of death (hazard ratio, 1.86 [95% CI, 1.10–3.14]; P=0.020), and increased spermines were associated with an increased risk of the primary outcome (odds ratio, 1.36 [95% CI, 1.08–1.71]; P=0.009) and major disability (odds ratio, 1.27 [95% CI, 1.01–1.59]; P=0.041). Conclusions Among patients with ischemic stroke, high plasma putrescine levels were associated with a decreased risk of adverse outcomes, whereas high plasma spermidine and spermine levels were associated with an increased risk of adverse outcomes. Further studies are needed to investigate whether targeting these polyamines can improve the prognosis of patients with ischemic stroke. Registration https://clinicaltrials.gov. Identifier: NCT01840072.https://www.ahajournals.org/doi/10.1161/JAHA.124.035837ischemic strokepolyaminesprognosisputrescinespermidineSpermine |
| spellingShingle | Pinni Yang Mengyao Shi Yiming Jia Chongke Zhong Hao Peng Lulu Sun Daoxia Guo Jing Chen Aili Wang Tan Xu Zhengbao Zhu Yonghong Zhang Jiang He Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ischemic stroke polyamines prognosis putrescine spermidine Spermine |
| title | Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study |
| title_full | Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study |
| title_fullStr | Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study |
| title_full_unstemmed | Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study |
| title_short | Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study |
| title_sort | plasma polyamines and short term adverse outcomes among patients with ischemic stroke a prospective cohort study |
| topic | ischemic stroke polyamines prognosis putrescine spermidine Spermine |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.035837 |
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