Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model
This study investigates the effects of lidocaine pre-emptive treatment on neuropathic pain behavior, injury discharges of nerves, neuropeptide Y (NPY) and c-Fos expression in the cuneate nucleus (CN) after median nerve chronic constriction injury (CCI). Behavior tests demonstrated that the pre-empti...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/921405 |
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| author | Chi-Te Lin Yi-Ju Tsai Hsin-Ying Wang Seu-Hwa Chen Tzu-Yu Lin June-Horng Lue |
| author_facet | Chi-Te Lin Yi-Ju Tsai Hsin-Ying Wang Seu-Hwa Chen Tzu-Yu Lin June-Horng Lue |
| author_sort | Chi-Te Lin |
| collection | DOAJ |
| description | This study investigates the effects of lidocaine pre-emptive treatment on neuropathic pain behavior, injury discharges of nerves, neuropeptide Y (NPY) and c-Fos expression in the cuneate nucleus (CN) after median nerve chronic constriction injury (CCI). Behavior tests demonstrated that the pre-emptive lidocaine treatment dose dependently delayed and attenuated the development of mechanical allodynia within a 28-day period. Electrophysiological recording was used to examine the changes in injury discharges of the nerves. An increase in frequency of injury discharges was observed and peaked at postelectrical stimulation stage in the presaline group, which was suppressed by lidocaine pre-emptive treatment in a dose-dependent manner. Lidocaine pretreatment also reduced the number of injury-induced NPY-like immunoreactive (NPY-LI) fibers and c-Fos-LI neurons within the CN in a dose-dependent manner. Furthermore, the mean number of c-Fos-LI neurons in the CN was significantly correlated to the NPY reduction level and the sign of mechanical allodynia following CCI. |
| format | Article |
| id | doaj-art-918b0698620b4f7ebcab8f2aa2602fa0 |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-918b0698620b4f7ebcab8f2aa2602fa02025-02-03T05:57:53ZengWileyAnesthesiology Research and Practice1687-69621687-69702012-01-01201210.1155/2012/921405921405Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury ModelChi-Te Lin0Yi-Ju Tsai1Hsin-Ying Wang2Seu-Hwa Chen3Tzu-Yu Lin4June-Horng Lue5Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10018, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, Taipei 24205, TaiwanDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10018, TaiwanDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10018, TaiwanDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10018, TaiwanDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10018, TaiwanThis study investigates the effects of lidocaine pre-emptive treatment on neuropathic pain behavior, injury discharges of nerves, neuropeptide Y (NPY) and c-Fos expression in the cuneate nucleus (CN) after median nerve chronic constriction injury (CCI). Behavior tests demonstrated that the pre-emptive lidocaine treatment dose dependently delayed and attenuated the development of mechanical allodynia within a 28-day period. Electrophysiological recording was used to examine the changes in injury discharges of the nerves. An increase in frequency of injury discharges was observed and peaked at postelectrical stimulation stage in the presaline group, which was suppressed by lidocaine pre-emptive treatment in a dose-dependent manner. Lidocaine pretreatment also reduced the number of injury-induced NPY-like immunoreactive (NPY-LI) fibers and c-Fos-LI neurons within the CN in a dose-dependent manner. Furthermore, the mean number of c-Fos-LI neurons in the CN was significantly correlated to the NPY reduction level and the sign of mechanical allodynia following CCI.http://dx.doi.org/10.1155/2012/921405 |
| spellingShingle | Chi-Te Lin Yi-Ju Tsai Hsin-Ying Wang Seu-Hwa Chen Tzu-Yu Lin June-Horng Lue Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model Anesthesiology Research and Practice |
| title | Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model |
| title_full | Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model |
| title_fullStr | Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model |
| title_full_unstemmed | Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model |
| title_short | Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model |
| title_sort | pre emptive treatment of lidocaine attenuates neuropathic pain and reduces pain related biochemical markers in the rat cuneate nucleus in median nerve chronic constriction injury model |
| url | http://dx.doi.org/10.1155/2012/921405 |
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