A Rare Presentation of Orbital Castleman’s Disease
Castleman’s disease (CD) is an uncommon group of atypical lymphoproliferative disorders. Extranodal involvement such as the orbit is extremely rare. We aim to report a case of a 62-year-old male who presented with left painless proptosis for the past three years. Examination revealed a firm, lobulat...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/1012759 |
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| author | Ruchi Goel Akash Raut Ayushi Agarwal Shweta Raghav Sumit Kumar Simmy Chaudhary Priyanka Golhait Sushil Kumar Ravindra Saran |
| author_facet | Ruchi Goel Akash Raut Ayushi Agarwal Shweta Raghav Sumit Kumar Simmy Chaudhary Priyanka Golhait Sushil Kumar Ravindra Saran |
| author_sort | Ruchi Goel |
| collection | DOAJ |
| description | Castleman’s disease (CD) is an uncommon group of atypical lymphoproliferative disorders. Extranodal involvement such as the orbit is extremely rare. We aim to report a case of a 62-year-old male who presented with left painless proptosis for the past three years. Examination revealed a firm, lobulated mass in the left superotemporal orbit, displacing the globe inferomedially. A well-defined extraconal orbital lesion encasing the left lateral rectus muscle with intraconal extension was seen on Magnetic Resonance Imaging (MRI) that led to the provisional diagnosis of left solitary encapsulated venous malformation. Excision of the mass via lateral orbitotomy was performed. However, on histopathology, the features were consistent with a mixed-cell variant of Castleman’s disease. A detailed systemic workup was unremarkable. Proptosis resolved after surgery and no recurrence was noted in the three-year follow-up. To the best of our knowledge, this is the first case report of a mixed-cell variant of unicentric orbital CD without any systemic features. This case highlights the importance of including CD in the differential diagnosis of well-defined orbital lesions so as to enable its early detection and timely management. |
| format | Article |
| id | doaj-art-918a666c753e447ab4026380172b2017 |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-918a666c753e447ab4026380172b20172025-02-03T06:46:00ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302020-01-01202010.1155/2020/10127591012759A Rare Presentation of Orbital Castleman’s DiseaseRuchi Goel0Akash Raut1Ayushi Agarwal2Shweta Raghav3Sumit Kumar4Simmy Chaudhary5Priyanka Golhait6Sushil Kumar7Ravindra Saran8Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaGuru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaGuru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaGuru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaGuru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaKallam Anji Reddy Campus, L V Prasad Marg, Banjara Hills, Hyderabad 500034, IndiaGuru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaGuru Nanak Eye Centre, Maulana Azad Medical College, New Delhi 110002, IndiaDepartment of Pathology, Govind Ballabh Pant Post Graduate Institute of Education and Medical Research, New Delhi 110002, IndiaCastleman’s disease (CD) is an uncommon group of atypical lymphoproliferative disorders. Extranodal involvement such as the orbit is extremely rare. We aim to report a case of a 62-year-old male who presented with left painless proptosis for the past three years. Examination revealed a firm, lobulated mass in the left superotemporal orbit, displacing the globe inferomedially. A well-defined extraconal orbital lesion encasing the left lateral rectus muscle with intraconal extension was seen on Magnetic Resonance Imaging (MRI) that led to the provisional diagnosis of left solitary encapsulated venous malformation. Excision of the mass via lateral orbitotomy was performed. However, on histopathology, the features were consistent with a mixed-cell variant of Castleman’s disease. A detailed systemic workup was unremarkable. Proptosis resolved after surgery and no recurrence was noted in the three-year follow-up. To the best of our knowledge, this is the first case report of a mixed-cell variant of unicentric orbital CD without any systemic features. This case highlights the importance of including CD in the differential diagnosis of well-defined orbital lesions so as to enable its early detection and timely management.http://dx.doi.org/10.1155/2020/1012759 |
| spellingShingle | Ruchi Goel Akash Raut Ayushi Agarwal Shweta Raghav Sumit Kumar Simmy Chaudhary Priyanka Golhait Sushil Kumar Ravindra Saran A Rare Presentation of Orbital Castleman’s Disease Case Reports in Ophthalmological Medicine |
| title | A Rare Presentation of Orbital Castleman’s Disease |
| title_full | A Rare Presentation of Orbital Castleman’s Disease |
| title_fullStr | A Rare Presentation of Orbital Castleman’s Disease |
| title_full_unstemmed | A Rare Presentation of Orbital Castleman’s Disease |
| title_short | A Rare Presentation of Orbital Castleman’s Disease |
| title_sort | rare presentation of orbital castleman s disease |
| url | http://dx.doi.org/10.1155/2020/1012759 |
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