Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes
Purpose: To compare the macular and peripapillary RNFL thicknesses of the amblyopic and normal eye in patients with anisometropic amblyopia. Methods: This is a hospital based cross-sectional study for which we studied 36 amblyopic subjects aged between 5 to 16 years in which the amblyopic eye was ta...
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Bucharest College of Physicians
2020-12-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2020/12/RMM_art-6.pdf |
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| author | Bharti NIGAM Pragati GARG Priyanka RAJ |
| author_facet | Bharti NIGAM Pragati GARG Priyanka RAJ |
| author_sort | Bharti NIGAM |
| collection | DOAJ |
| description | Purpose: To compare the macular and peripapillary RNFL thicknesses of the amblyopic and normal eye in patients with anisometropic amblyopia. Methods: This is a hospital based cross-sectional study for which we studied 36 amblyopic subjects aged between 5 to 16 years in which the amblyopic eye was taken as the case and the unaffected eye was taken as control eye. The inclusion criteria included children having unilateral strabismic or anisometropic amblyopia who underwent macular and RNFL thickness assessment by SD-OCT. Results: Central Macular thickness as well as the thickness of the other macular segments was significantly greater in the affected eye (p<0.001) as compared to the normal eye. The average RNFL thickness was also found to be increased in the affected eye but the difference was not statistically significant (p=0.106), however it was statistically significant in quadrantic analysis (p<0.05). The Central Macular thickness showed a negative correlation with the BCVA (r=-0.252), although it was not statistically significant (p=0.139). Conclusion: A significant increase was found in the macular as well as RNFL thickness in the amblyopic eyes as compared to the normal fellow eye which support the hypothesis of decreased apoptosis of the ganglion cells postnatally. |
| format | Article |
| id | doaj-art-91889e19263e495c926e1f21e19652e1 |
| institution | DOAJ |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-91889e19263e495c926e1f21e19652e12025-08-20T02:56:58ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732020-12-01274289294https://doi.org/10.31689/rmm.2020.27.4.289Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow EyesBharti NIGAM0Pragati GARG1https://orcid.org/0000-0002-6811-3779Priyanka RAJ2https://orcid.org/0000-0002-4915-6212Department of Ophthalmology, Era’s Lucknow Medical College and Hospital, Sarfarazganj, Uttar Pradesh, IndiaDepartment of Ophthalmology, Era’s Lucknow Medical College and Hospital, Sarfarazganj, Uttar Pradesh, IndiaDepartment of Ophthalmology, Era’s Lucknow Medical College and Hospital, Sarfarazganj, Uttar Pradesh, IndiaPurpose: To compare the macular and peripapillary RNFL thicknesses of the amblyopic and normal eye in patients with anisometropic amblyopia. Methods: This is a hospital based cross-sectional study for which we studied 36 amblyopic subjects aged between 5 to 16 years in which the amblyopic eye was taken as the case and the unaffected eye was taken as control eye. The inclusion criteria included children having unilateral strabismic or anisometropic amblyopia who underwent macular and RNFL thickness assessment by SD-OCT. Results: Central Macular thickness as well as the thickness of the other macular segments was significantly greater in the affected eye (p<0.001) as compared to the normal eye. The average RNFL thickness was also found to be increased in the affected eye but the difference was not statistically significant (p=0.106), however it was statistically significant in quadrantic analysis (p<0.05). The Central Macular thickness showed a negative correlation with the BCVA (r=-0.252), although it was not statistically significant (p=0.139). Conclusion: A significant increase was found in the macular as well as RNFL thickness in the amblyopic eyes as compared to the normal fellow eye which support the hypothesis of decreased apoptosis of the ganglion cells postnatally.https://medicinamoderna.ro/wp-content/uploads/2020/12/RMM_art-6.pdfrnfl thicknessamblyopiamacular thicknessanisometropianerve fibre layer |
| spellingShingle | Bharti NIGAM Pragati GARG Priyanka RAJ Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes Modern Medicine rnfl thickness amblyopia macular thickness anisometropia nerve fibre layer |
| title | Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes |
| title_full | Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes |
| title_fullStr | Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes |
| title_full_unstemmed | Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes |
| title_short | Comparison of Macular and RNFL Thickness in Anisometropic Amblyopia as Compared to Normal Fellow Eyes |
| title_sort | comparison of macular and rnfl thickness in anisometropic amblyopia as compared to normal fellow eyes |
| topic | rnfl thickness amblyopia macular thickness anisometropia nerve fibre layer |
| url | https://medicinamoderna.ro/wp-content/uploads/2020/12/RMM_art-6.pdf |
| work_keys_str_mv | AT bhartinigam comparisonofmacularandrnflthicknessinanisometropicamblyopiaascomparedtonormalfelloweyes AT pragatigarg comparisonofmacularandrnflthicknessinanisometropicamblyopiaascomparedtonormalfelloweyes AT priyankaraj comparisonofmacularandrnflthicknessinanisometropicamblyopiaascomparedtonormalfelloweyes |