Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment
Abstract Background It is well known that the incidence of developing hepatocelluler carcinoma (HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC incidence in various liver diseases has not yet been estimated. We surveyed this comparison. Methods The PubMed dat...
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Wiley
2019-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1998 |
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| author | Kazuo Tarao Akito Nozaki Takaaki Ikeda Akira Sato Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka |
| author_facet | Kazuo Tarao Akito Nozaki Takaaki Ikeda Akira Sato Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka |
| author_sort | Kazuo Tarao |
| collection | DOAJ |
| description | Abstract Background It is well known that the incidence of developing hepatocelluler carcinoma (HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC incidence in various liver diseases has not yet been estimated. We surveyed this comparison. Methods The PubMed database was examined (1989‐2017) for studies published in English language regarding the prospective follow‐up results for the development of HCC in various liver diseases. A meta‐analysis was performed for each liver disease. Results The annual incidence (%) of HCC in the non‐cirrhotic stage and cirrhotic stage, and the ratio of HCC incidence in the cirrhotic stage/non‐cirrhotic stage were as follows. (a) hepatitis B virus liver disease: 0.37%→3.23% (8.73‐fold), (b) hepatitis C virus liver diseases: 0.68%→4.81% (7.07‐fold), (c) primary biliary cholangitis (0.26%→1.79%, 6.88‐fold), (d) autoimmune hepatitis (0.19%→0.53%, 2.79‐fold), and (e) NASH (0.03%→1.35%, 45.00‐fold). Regarding primary hemochromatosis and alcoholic liver diseases, only follow‐up studies in the cirrhotic stage were presented, 1.20% and 2.06%, respectively. Conclusions When the liver diseases advance to cirrhosis, the incidence of HCC is markedly increased. The development of HCC must be closely monitored by ultrasonography, magnetic resonance imaging, and computed tomography, irrespective of the different kinds of liver diseases. |
| format | Article |
| id | doaj-art-917e83215cb3434baf77b3b8c3145ee1 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-917e83215cb3434baf77b3b8c3145ee12025-01-31T08:47:42ZengWileyCancer Medicine2045-76342019-03-01831054106510.1002/cam4.1998Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessmentKazuo Tarao0Akito Nozaki1Takaaki Ikeda2Akira Sato3Hirokazu Komatsu4Tatsuji Komatsu5Masataka Taguri6Katsuaki Tanaka7Tarao’s Gastroenterological Clinic Yokohama JapanGastroenterological Center, Medical Center Yokohama City University Yokohama JapanGastroenterology Department Yokosuka General Hospital Uwamachi Yokosuka JapanDivision of Gastroenterology, Department of Internal Medicine St. Marianna University, Yokohama City Seibu Hospital Yokohama JapanDepartment of Gastroenterology Yokohama Municipal Citizen’s Hospital Yokohama JapanDepartment Clinical Research National Hospital Organization, Yokohama Medical Center Yokohama JapanDepartment of Data Science Yokohama City University Yokohama JapanHatano Red Cross Hospital Kanagawa JapanAbstract Background It is well known that the incidence of developing hepatocelluler carcinoma (HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC incidence in various liver diseases has not yet been estimated. We surveyed this comparison. Methods The PubMed database was examined (1989‐2017) for studies published in English language regarding the prospective follow‐up results for the development of HCC in various liver diseases. A meta‐analysis was performed for each liver disease. Results The annual incidence (%) of HCC in the non‐cirrhotic stage and cirrhotic stage, and the ratio of HCC incidence in the cirrhotic stage/non‐cirrhotic stage were as follows. (a) hepatitis B virus liver disease: 0.37%→3.23% (8.73‐fold), (b) hepatitis C virus liver diseases: 0.68%→4.81% (7.07‐fold), (c) primary biliary cholangitis (0.26%→1.79%, 6.88‐fold), (d) autoimmune hepatitis (0.19%→0.53%, 2.79‐fold), and (e) NASH (0.03%→1.35%, 45.00‐fold). Regarding primary hemochromatosis and alcoholic liver diseases, only follow‐up studies in the cirrhotic stage were presented, 1.20% and 2.06%, respectively. Conclusions When the liver diseases advance to cirrhosis, the incidence of HCC is markedly increased. The development of HCC must be closely monitored by ultrasonography, magnetic resonance imaging, and computed tomography, irrespective of the different kinds of liver diseases.https://doi.org/10.1002/cam4.1998hepatocellular carcinomaliver cirrhosisliver diseasesmeta‐analysisrisk of HCC |
| spellingShingle | Kazuo Tarao Akito Nozaki Takaaki Ikeda Akira Sato Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment Cancer Medicine hepatocellular carcinoma liver cirrhosis liver diseases meta‐analysis risk of HCC |
| title | Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment |
| title_full | Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment |
| title_fullStr | Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment |
| title_full_unstemmed | Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment |
| title_short | Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment |
| title_sort | real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases meta analytic assessment |
| topic | hepatocellular carcinoma liver cirrhosis liver diseases meta‐analysis risk of HCC |
| url | https://doi.org/10.1002/cam4.1998 |
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