Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis
The diagnosis and management of irritable bowel syndrome (IBS) is challenging due to its complex symptoms and inconsistent treatment responses. Given the important role of gut microbiota in gastrointestinal health, fecal microbiota transplantation (FMT) is a promising intervention. We describe the c...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Gut Microbes Reports |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/29933935.2025.2487905 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849425048852496384 |
|---|---|
| author | Elena Montenegro-Borbolla Jeanine Wakim El-Khoury Claire Bertelli Alain Schoepfer Benoît Guery Tatiana Galperine |
| author_facet | Elena Montenegro-Borbolla Jeanine Wakim El-Khoury Claire Bertelli Alain Schoepfer Benoît Guery Tatiana Galperine |
| author_sort | Elena Montenegro-Borbolla |
| collection | DOAJ |
| description | The diagnosis and management of irritable bowel syndrome (IBS) is challenging due to its complex symptoms and inconsistent treatment responses. Given the important role of gut microbiota in gastrointestinal health, fecal microbiota transplantation (FMT) is a promising intervention. We describe the case of a 55-y-old woman without prior gastrointestinal issues who, following severe depression, developed multiple gastrointestinal symptoms, including abdominal pain, fluctuating bowel habits, and a persistent burning sensation in her mouth and upper gastrointestinal tract. At Lausanne University Hospital, she was diagnosed with IBS resistant to multiple lines of treatment and a multidisciplinary team proposed multiple oral FMTs. One-month post-FMT, her gastrointestinal symptoms significantly improved and remained better after a year, with only the burning sensation persisting. Analysis of pre- and post-FMT samples and donor material, using 16S rRNA amplicon metagenomics, revealed a 90% genus-level taxonomic overlap between the patient and the donor. The observed changes in the relative abundance of these genera, including the enrichment of beneficial gut commensals, as well as the elimination of IBS-associated genera likely supported her recovery. Overall, FMT led to substantial improvement in her long-standing gastrointestinal symptoms. |
| format | Article |
| id | doaj-art-917c1bb3e1384314b79da541c237fd84 |
| institution | Kabale University |
| issn | 2993-3935 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes Reports |
| spelling | doaj-art-917c1bb3e1384314b79da541c237fd842025-08-20T03:29:53ZengTaylor & Francis GroupGut Microbes Reports2993-39352025-12-012110.1080/29933935.2025.2487905Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysisElena Montenegro-Borbolla0Jeanine Wakim El-Khoury1Claire Bertelli2Alain Schoepfer3Benoît Guery4Tatiana Galperine5Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDivision of Gastroenterology and Hepatology, University Hospital Lausanne - CHUV, Lausanne, SwitzerlandInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDivision of Gastroenterology and Hepatology, University Hospital Lausanne - CHUV, Lausanne, SwitzerlandInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandThe diagnosis and management of irritable bowel syndrome (IBS) is challenging due to its complex symptoms and inconsistent treatment responses. Given the important role of gut microbiota in gastrointestinal health, fecal microbiota transplantation (FMT) is a promising intervention. We describe the case of a 55-y-old woman without prior gastrointestinal issues who, following severe depression, developed multiple gastrointestinal symptoms, including abdominal pain, fluctuating bowel habits, and a persistent burning sensation in her mouth and upper gastrointestinal tract. At Lausanne University Hospital, she was diagnosed with IBS resistant to multiple lines of treatment and a multidisciplinary team proposed multiple oral FMTs. One-month post-FMT, her gastrointestinal symptoms significantly improved and remained better after a year, with only the burning sensation persisting. Analysis of pre- and post-FMT samples and donor material, using 16S rRNA amplicon metagenomics, revealed a 90% genus-level taxonomic overlap between the patient and the donor. The observed changes in the relative abundance of these genera, including the enrichment of beneficial gut commensals, as well as the elimination of IBS-associated genera likely supported her recovery. Overall, FMT led to substantial improvement in her long-standing gastrointestinal symptoms.https://www.tandfonline.com/doi/10.1080/29933935.2025.2487905Irritable bowel syndromeIBS-Cfecal microbiota transplantation (FMT)microbiota analysisengraftment |
| spellingShingle | Elena Montenegro-Borbolla Jeanine Wakim El-Khoury Claire Bertelli Alain Schoepfer Benoît Guery Tatiana Galperine Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis Gut Microbes Reports Irritable bowel syndrome IBS-C fecal microbiota transplantation (FMT) microbiota analysis engraftment |
| title | Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis |
| title_full | Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis |
| title_fullStr | Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis |
| title_full_unstemmed | Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis |
| title_short | Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis |
| title_sort | resolution of long term severe irritable bowel syndrome following fecal microbiota transplantation a case report and microbiota analysis |
| topic | Irritable bowel syndrome IBS-C fecal microbiota transplantation (FMT) microbiota analysis engraftment |
| url | https://www.tandfonline.com/doi/10.1080/29933935.2025.2487905 |
| work_keys_str_mv | AT elenamontenegroborbolla resolutionoflongtermsevereirritablebowelsyndromefollowingfecalmicrobiotatransplantationacasereportandmicrobiotaanalysis AT jeaninewakimelkhoury resolutionoflongtermsevereirritablebowelsyndromefollowingfecalmicrobiotatransplantationacasereportandmicrobiotaanalysis AT clairebertelli resolutionoflongtermsevereirritablebowelsyndromefollowingfecalmicrobiotatransplantationacasereportandmicrobiotaanalysis AT alainschoepfer resolutionoflongtermsevereirritablebowelsyndromefollowingfecalmicrobiotatransplantationacasereportandmicrobiotaanalysis AT benoitguery resolutionoflongtermsevereirritablebowelsyndromefollowingfecalmicrobiotatransplantationacasereportandmicrobiotaanalysis AT tatianagalperine resolutionoflongtermsevereirritablebowelsyndromefollowingfecalmicrobiotatransplantationacasereportandmicrobiotaanalysis |