Investigation of the Roles of the Adenosine A(2A) and Metabotropic Glutamate Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis

Investigation of the Roles of the Adenosine A(2A) and Metabotropic Glutamate Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis

The metabotropic glutamate receptor type 5 (mGlu5) and adenosine A(2A) receptor form a mutually inhibitory heteromer with the dopamine D2 receptor, where the activation of either mGlu5 or A(2A) leads to reduced D2 signaling. This study investigated whether a mGlu5-positive allosteric modulator (PAM)...

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Bibliographic Details
Main Authors: Anthony M. Cuozzo, Loren D. Peeters, Cristal D. Ahmed, Liza J. Wills, Justin T. Gass, Russell W. Brown
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
mGlu5
A(2A)
dopamine
CREB
prepulse inhibition
psychosis
Online Access:https://www.mdpi.com/2073-4409/14/3/182
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