Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

Abstract The highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses, responsible for the current outbreak in dairy cows in the United States, pose a significant animal and public health threat. In this study, we compare disease progression and pathology of three recent clade 2.3.4.4...

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Main Authors: Thomas Tipih, Vignesh Mariappan, Kwe C. Yinda, Kimberly Meade-White, Matthew Lewis, Atsushi Okumura, Natalie McCarthy, Ekaterina Altynova, Shanna S. Leventhal, Trenton Bushmaker, Chad S. Clancy, Emmie de Wit, Vincent J. Munster, Heinz Feldmann, Kyle Rosenke
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60407-y
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