Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations
The case reported is a young “light” ex-smoker who initially had a localized adenosquamous carcinoma bearing an epidermal growth factor receptor (EGFR) sensitizing mutation. He first recurred six months after initial treatment within the brain with a pure squamous histology and the same EGFR mutat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2015/283875 |
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| _version_ | 1849404081916870656 |
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| author | Jarred Burkart Konstantin Shilo Weiqiang Zhao Efe Ozkan Amna Ajam Gregory A. Otterson |
| author_facet | Jarred Burkart Konstantin Shilo Weiqiang Zhao Efe Ozkan Amna Ajam Gregory A. Otterson |
| author_sort | Jarred Burkart |
| collection | DOAJ |
| description | The case reported is a young “light” ex-smoker who initially had a localized adenosquamous carcinoma bearing an epidermal growth factor receptor (EGFR) sensitizing mutation. He first recurred six months after initial treatment within the brain with a pure squamous histology and the same EGFR mutation. Surgical resection and radiation rendered him disease-free. Subsequent isolated recurrence within the lung eighteen months later was a pure adenocarcinoma, again with the same identified EGFR mutation. These histologic changes (from adenosquamous to pure squamous to pure adenocarcinoma) have been described but not before in the absence of any selection pressure with EGFR tyrosine kinase inhibitors. This case points out the histologic “flexibility” of EGFR mutant lung cancers and the importance for appropriate molecular testing in nonsmokers with lung cancer of any histologic type. |
| format | Article |
| id | doaj-art-91672c2f20864db58c72b3a3d054bb49 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-91672c2f20864db58c72b3a3d054bb492025-08-20T03:37:06ZengWileyCase Reports in Pulmonology2090-68462090-68542015-01-01201510.1155/2015/283875283875Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor MutationsJarred Burkart0Konstantin Shilo1Weiqiang Zhao2Efe Ozkan3Amna Ajam4Gregory A. Otterson5Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USADepartment of Pathology, The Ohio State University College of Medicine, Columbus, OH 43210, USADepartment of Pathology, The Ohio State University College of Medicine, Columbus, OH 43210, USADepartment of Radiology, The Ohio State University College of Medicine, Columbus, OH 43210, USADepartment of Radiology, The Ohio State University College of Medicine, Columbus, OH 43210, USADepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USAThe case reported is a young “light” ex-smoker who initially had a localized adenosquamous carcinoma bearing an epidermal growth factor receptor (EGFR) sensitizing mutation. He first recurred six months after initial treatment within the brain with a pure squamous histology and the same EGFR mutation. Surgical resection and radiation rendered him disease-free. Subsequent isolated recurrence within the lung eighteen months later was a pure adenocarcinoma, again with the same identified EGFR mutation. These histologic changes (from adenosquamous to pure squamous to pure adenocarcinoma) have been described but not before in the absence of any selection pressure with EGFR tyrosine kinase inhibitors. This case points out the histologic “flexibility” of EGFR mutant lung cancers and the importance for appropriate molecular testing in nonsmokers with lung cancer of any histologic type.http://dx.doi.org/10.1155/2015/283875 |
| spellingShingle | Jarred Burkart Konstantin Shilo Weiqiang Zhao Efe Ozkan Amna Ajam Gregory A. Otterson Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations Case Reports in Pulmonology |
| title | Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations |
| title_full | Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations |
| title_fullStr | Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations |
| title_full_unstemmed | Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations |
| title_short | Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations |
| title_sort | metastatic squamous cell carcinoma component from an adenosquamous carcinoma of the lung with identical epidermal growth factor receptor mutations |
| url | http://dx.doi.org/10.1155/2015/283875 |
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