Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes

Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes

Objective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux and metabolism of excess cholesterol, and sma...

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Bibliographic Details
Main Authors: Bahar Jaberian Asl, Zahra Nazeri, Seyadeh Pardis Pezeshki, Alireza Kheirollah, Shirin Azizidoost, Maryam Adelipour, Maryam Cheraghzadeh
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2024-11-01
Series:Cell Journal
Subjects:
amyloid beta-peptides
apolipoproteins e
cholesterol
cholesterol 24-hydroxylase
micrornas
Online Access:https://www.celljournal.org/article_720543_29ee4896f9e7ea1b53b3f7ed01780a0a.pdf
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