Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development
Plant- and marine-derived natural products are rich sources of bioactive compounds essential for drug discovery. These compounds contain complex mixtures of metabolites, which collectively contribute to their pharmacological properties. However, challenges arise in the isolation of individual bioact...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1497668/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558782479433728 |
|---|---|
| author | Muhammad Ahmad Muhammad Ahmad Maleha Tahir Zibin Hong Muhammad Anjum Zia Hamza Rafeeq Muhammad Shaheez Ahmad Saif ur Rehman Junming Sun |
| author_facet | Muhammad Ahmad Muhammad Ahmad Maleha Tahir Zibin Hong Muhammad Anjum Zia Hamza Rafeeq Muhammad Shaheez Ahmad Saif ur Rehman Junming Sun |
| author_sort | Muhammad Ahmad |
| collection | DOAJ |
| description | Plant- and marine-derived natural products are rich sources of bioactive compounds essential for drug discovery. These compounds contain complex mixtures of metabolites, which collectively contribute to their pharmacological properties. However, challenges arise in the isolation of individual bioactive compounds, owing to their intricate chemistry and low abundance in natural extracts. Despite these limitations, numerous plant and marine-derived compounds have achieved regulatory approval, particularly for treating cancer and infectious diseases. This review explores the therapeutic potential of plant and marine sources along with innovative extraction and isolation methods that support sustainable drug development. Future perspectives will highlight the role of responsible innovation, artificial intelligence, and machine learning in advancing drug discovery, underscoring the importance of continued research to meet global health needs. |
| format | Article |
| id | doaj-art-9156e3b93a424dc485c8d11e8e31d383 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-9156e3b93a424dc485c8d11e8e31d3832025-01-06T06:58:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14976681497668Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic developmentMuhammad Ahmad0Muhammad Ahmad1Maleha Tahir2Zibin Hong3Muhammad Anjum Zia4Hamza Rafeeq5Muhammad Shaheez Ahmad6Saif ur Rehman7Junming Sun8Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital-Ganzhou Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaInstitute of Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture Faisalabad, Faisalabad, PakistanGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital-Ganzhou Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital-Ganzhou Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaEnzyme Biotechnology Lab, Department of Biochemistry, University of Agriculture Faisalabad, Faisalabad, PakistanEnzyme Biotechnology Lab, Department of Biochemistry, University of Agriculture Faisalabad, Faisalabad, PakistanEnzyme Biotechnology Lab, Department of Biochemistry, University of Agriculture Faisalabad, Faisalabad, PakistanGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital-Ganzhou Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaLaboratory Animal Center, Guangxi Medical University, Nanning, Guangxi, ChinaPlant- and marine-derived natural products are rich sources of bioactive compounds essential for drug discovery. These compounds contain complex mixtures of metabolites, which collectively contribute to their pharmacological properties. However, challenges arise in the isolation of individual bioactive compounds, owing to their intricate chemistry and low abundance in natural extracts. Despite these limitations, numerous plant and marine-derived compounds have achieved regulatory approval, particularly for treating cancer and infectious diseases. This review explores the therapeutic potential of plant and marine sources along with innovative extraction and isolation methods that support sustainable drug development. Future perspectives will highlight the role of responsible innovation, artificial intelligence, and machine learning in advancing drug discovery, underscoring the importance of continued research to meet global health needs.https://www.frontiersin.org/articles/10.3389/fphar.2024.1497668/fullbioactive compoundsbioprospectingbiosynthetic pathwaysmetabolitesgene clusterantioxidants |
| spellingShingle | Muhammad Ahmad Muhammad Ahmad Maleha Tahir Zibin Hong Muhammad Anjum Zia Hamza Rafeeq Muhammad Shaheez Ahmad Saif ur Rehman Junming Sun Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development Frontiers in Pharmacology bioactive compounds bioprospecting biosynthetic pathways metabolites gene cluster antioxidants |
| title | Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development |
| title_full | Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development |
| title_fullStr | Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development |
| title_full_unstemmed | Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development |
| title_short | Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development |
| title_sort | plant and marine derived natural products sustainable pathways for future drug discovery and therapeutic development |
| topic | bioactive compounds bioprospecting biosynthetic pathways metabolites gene cluster antioxidants |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1497668/full |
| work_keys_str_mv | AT muhammadahmad plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT muhammadahmad plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT malehatahir plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT zibinhong plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT muhammadanjumzia plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT hamzarafeeq plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT muhammadshaheezahmad plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT saifurrehman plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment AT junmingsun plantandmarinederivednaturalproductssustainablepathwaysforfuturedrugdiscoveryandtherapeuticdevelopment |