SEPT9 and PAI-1 are immunohistochemical biomarkers of the hepatocellular carcinoma immune microenvironment

SEPT9 and PAI-1 are immunohistochemical biomarkers of the hepatocellular carcinoma immune microenvironment

Abstract Background Septin 9 (SEPT9) interacts with multiple oncogenic proteins and is expressed abnormally in several cancers, including hepatocellular carcinoma (HCC). Plasminogen activator inhibitor-1 (PAI-1) promotes tumor formation and progression by modulating the tumor immune microenvironment...

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Bibliographic Details
Main Authors: Eundong Park, Xin Wang, Nusret Bekir Subasi, Michel Kmeid, Paul J. Higgins, Anne Chen, Hwajeong Lee
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
SEPT9
PAI-1
HCC
CXCR2
Tumor microenvironment
Online Access:https://doi.org/10.1007/s12672-025-02252-5
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