Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne
OBJECTIVE: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). METHOD: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelli...
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Thieme Revinter Publicações
2007-03-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100013 |
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| author | Marcus Vinicius Della Coletta Rosana Herminia Scola Gislaine Richter Minhoto Wiemes Cláudia Nasser Fonseca Maria Joana Mäder Aline Andrade Freund Lineu César Werneck |
| author_facet | Marcus Vinicius Della Coletta Rosana Herminia Scola Gislaine Richter Minhoto Wiemes Cláudia Nasser Fonseca Maria Joana Mäder Aline Andrade Freund Lineu César Werneck |
| author_sort | Marcus Vinicius Della Coletta |
| collection | DOAJ |
| description | OBJECTIVE: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). METHOD: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05). RESULTS: The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group. CONCLUSION: DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.<br>OBJETIVO: Avaliar potenciais evocados cognitivos auditivos (P300) e disfunções neuropsicológicas em pacientes com distrofia muscular de Duchenne (DMD). MÉTODO: Potenciais auditivos P300 e testes neuropsicológicos foram obtidos de 16 controles e 20 pacientes com DMD. Valores de quociente de inteligência (QI) foram estimados para os dois grupos. A media de idade foi de 9.5 anos no grupo DMD e 10 anos no grupo controle (p>0.05). RESULTADOS: Os valores médios de QI foram 64.35 no grupo DMD e 82.68 no grupo controle (p=0.01). A média de valores de P300 foi 347.6 no grupo DMD e 337.4 no grupo controle (p=0.14). Não houve correlação significativa entre os parâmetros em cada grupo. CONCLUSÃO: Os pacientes com DMD mostraram um pior desempenho nas testagens de P300 quando comparados com o grupo controle, embora a diferença não tenha apresentado diferença significativa. Alterações sistemáticas foram encontradas nos testes neuropsicológicos, correspondendo às alterações significativas vistas nos valores de QI. |
| format | Article |
| id | doaj-art-915562e346374c31be8b03de7ccb58bd |
| institution | Kabale University |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2007-03-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-915562e346374c31be8b03de7ccb58bd2025-08-20T03:37:06ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272007-03-01651596210.1590/S0004-282X2007000100013Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de DuchenneMarcus Vinicius Della ColettaRosana Herminia ScolaGislaine Richter Minhoto WiemesCláudia Nasser FonsecaMaria Joana MäderAline Andrade FreundLineu César WerneckOBJECTIVE: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). METHOD: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05). RESULTS: The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group. CONCLUSION: DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.<br>OBJETIVO: Avaliar potenciais evocados cognitivos auditivos (P300) e disfunções neuropsicológicas em pacientes com distrofia muscular de Duchenne (DMD). MÉTODO: Potenciais auditivos P300 e testes neuropsicológicos foram obtidos de 16 controles e 20 pacientes com DMD. Valores de quociente de inteligência (QI) foram estimados para os dois grupos. A media de idade foi de 9.5 anos no grupo DMD e 10 anos no grupo controle (p>0.05). RESULTADOS: Os valores médios de QI foram 64.35 no grupo DMD e 82.68 no grupo controle (p=0.01). A média de valores de P300 foi 347.6 no grupo DMD e 337.4 no grupo controle (p=0.14). Não houve correlação significativa entre os parâmetros em cada grupo. CONCLUSÃO: Os pacientes com DMD mostraram um pior desempenho nas testagens de P300 quando comparados com o grupo controle, embora a diferença não tenha apresentado diferença significativa. Alterações sistemáticas foram encontradas nos testes neuropsicológicos, correspondendo às alterações significativas vistas nos valores de QI.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100013P300distrofia muscular de Duchennedisfunção neuropsicológicaP300Duchenne muscular dystrophyneuropsychologic dysfunction |
| spellingShingle | Marcus Vinicius Della Coletta Rosana Herminia Scola Gislaine Richter Minhoto Wiemes Cláudia Nasser Fonseca Maria Joana Mäder Aline Andrade Freund Lineu César Werneck Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne Arquivos de Neuro-Psiquiatria P300 distrofia muscular de Duchenne disfunção neuropsicológica P300 Duchenne muscular dystrophy neuropsychologic dysfunction |
| title | Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne |
| title_full | Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne |
| title_fullStr | Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne |
| title_full_unstemmed | Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne |
| title_short | Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy Potencial evocado cognitivo (P300) e testagem neuropsicológica em pacientes com distrofia muscular de Duchenne |
| title_sort | event related potentials p300 and neuropsychological assessment in boys exhibiting duchenne muscular dystrophy potencial evocado cognitivo p300 e testagem neuropsicologica em pacientes com distrofia muscular de duchenne |
| topic | P300 distrofia muscular de Duchenne disfunção neuropsicológica P300 Duchenne muscular dystrophy neuropsychologic dysfunction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100013 |
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