Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Abstract The widespread occurrence of microplastics (MPs) in the environment has raised significant concerns regarding their potential health impacts, particularly in relation to carcinogenesis. This study aimed to identify and analyze microplastics present in peritumoral and tumor tissues of patien...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-98268-6 |
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| author | Wen Pan Jie Hao Mingqing Zhang Hui Liu Fei Tian Xipeng Zhang Zhansheng Jiang Chong Chen Ming Gao Haiyang Zhang |
| author_facet | Wen Pan Jie Hao Mingqing Zhang Hui Liu Fei Tian Xipeng Zhang Zhansheng Jiang Chong Chen Ming Gao Haiyang Zhang |
| author_sort | Wen Pan |
| collection | DOAJ |
| description | Abstract The widespread occurrence of microplastics (MPs) in the environment has raised significant concerns regarding their potential health impacts, particularly in relation to carcinogenesis. This study aimed to identify and analyze microplastics present in peritumoral and tumor tissues of patients diagnosed with colorectal cancer (CRC). Utilizing advanced scanning electron microscopy (SEM) and laser direct infrared (LDIR) imaging systems, we systematically examined tissue samples to detect and characterize the microplastics. Our findings revealed a diverse array of microplastic types, notably polyvinyl chloride (PVC) and polyethylene (PE), within both peritumoral and tumor regions. Compared to adjacent non-cancerous tissues, tumor tissues exhibited a greater variety and distribution of microplastics. Furthermore, Clathrin—a key protein involved in endocytosis—was found to be highly expressed in colorectal cancer specimens, facilitating the substantial uptake of microplastics. These results suggest a potential association between exposure to microplastics and the pathogenesis of colorectal cancer. This study highlights the urgent need for increased awareness and regulatory measures aimed at mitigating microplastic pollution along with its associated health risks. |
| format | Article |
| id | doaj-art-914e32c8989246618667b26bbd80bd47 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-914e32c8989246618667b26bbd80bd472025-08-20T01:49:42ZengNature PortfolioScientific Reports2045-23222025-05-0115111310.1038/s41598-025-98268-6Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancerWen Pan0Jie Hao1Mingqing Zhang2Hui Liu3Fei Tian4Xipeng Zhang5Zhansheng Jiang6Chong Chen7Ming Gao8Haiyang Zhang9Tianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineTianjin Institute of Coloproctology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Instituteand Hospital, National Clinical Research Center for Cancer, Tianjin Cancer Institute of Integrative Traditional Chinese and Western MedicineAbstract The widespread occurrence of microplastics (MPs) in the environment has raised significant concerns regarding their potential health impacts, particularly in relation to carcinogenesis. This study aimed to identify and analyze microplastics present in peritumoral and tumor tissues of patients diagnosed with colorectal cancer (CRC). Utilizing advanced scanning electron microscopy (SEM) and laser direct infrared (LDIR) imaging systems, we systematically examined tissue samples to detect and characterize the microplastics. Our findings revealed a diverse array of microplastic types, notably polyvinyl chloride (PVC) and polyethylene (PE), within both peritumoral and tumor regions. Compared to adjacent non-cancerous tissues, tumor tissues exhibited a greater variety and distribution of microplastics. Furthermore, Clathrin—a key protein involved in endocytosis—was found to be highly expressed in colorectal cancer specimens, facilitating the substantial uptake of microplastics. These results suggest a potential association between exposure to microplastics and the pathogenesis of colorectal cancer. This study highlights the urgent need for increased awareness and regulatory measures aimed at mitigating microplastic pollution along with its associated health risks.https://doi.org/10.1038/s41598-025-98268-6MicroplasticsColorectal cancerLaser direct infrared imagingEndocytosisHealth risks |
| spellingShingle | Wen Pan Jie Hao Mingqing Zhang Hui Liu Fei Tian Xipeng Zhang Zhansheng Jiang Chong Chen Ming Gao Haiyang Zhang Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer Scientific Reports Microplastics Colorectal cancer Laser direct infrared imaging Endocytosis Health risks |
| title | Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer |
| title_full | Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer |
| title_fullStr | Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer |
| title_full_unstemmed | Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer |
| title_short | Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer |
| title_sort | identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer |
| topic | Microplastics Colorectal cancer Laser direct infrared imaging Endocytosis Health risks |
| url | https://doi.org/10.1038/s41598-025-98268-6 |
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