Toxin-Induced and Genetic Animal Models of Parkinson's Disease
Parkinson's disease (PD) is a common progressive neurodegenerative disorder. The major pathological hallmarks of PD are the selective loss of nigrostriatal dopaminergic neurons and the presence of intraneuronal aggregates termed Lewy bodies (LBs), but the pathophysiological mechanisms are not f...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/951709 |
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| author | Shin Hisahara Shun Shimohama |
| author_facet | Shin Hisahara Shun Shimohama |
| author_sort | Shin Hisahara |
| collection | DOAJ |
| description | Parkinson's disease (PD) is a common progressive neurodegenerative disorder. The major pathological hallmarks of PD are the selective loss of nigrostriatal dopaminergic neurons and the presence of intraneuronal aggregates termed Lewy bodies (LBs), but the pathophysiological mechanisms are not fully understood. Epidemiologically, environmental neurotoxins such as pesticides are promising candidates for causative factors of PD. Oxidative stress and mitochondrial dysfunction induced by these toxins could contribute to the progression of PD. While most cases of PD are sporadic, specific mutations in genes that cause familial forms of PD have led to provide new insights into its pathogenesis. This paper focuses on animal models of both toxin-induced and genetically determined PD that have provided significant insight for understanding this disease. We also discuss the validity, benefits, and limitations of representative models. |
| format | Article |
| id | doaj-art-9147f209706146d4be0e474b971364cf |
| institution | OA Journals |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-9147f209706146d4be0e474b971364cf2025-08-20T02:09:44ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/951709951709Toxin-Induced and Genetic Animal Models of Parkinson's DiseaseShin Hisahara0Shun Shimohama1Department of Neurology, Sapporo Medical University, South1, West17, chuo-ku, Sapporo 060-8556, JapanDepartment of Neurology, Sapporo Medical University, South1, West17, chuo-ku, Sapporo 060-8556, JapanParkinson's disease (PD) is a common progressive neurodegenerative disorder. The major pathological hallmarks of PD are the selective loss of nigrostriatal dopaminergic neurons and the presence of intraneuronal aggregates termed Lewy bodies (LBs), but the pathophysiological mechanisms are not fully understood. Epidemiologically, environmental neurotoxins such as pesticides are promising candidates for causative factors of PD. Oxidative stress and mitochondrial dysfunction induced by these toxins could contribute to the progression of PD. While most cases of PD are sporadic, specific mutations in genes that cause familial forms of PD have led to provide new insights into its pathogenesis. This paper focuses on animal models of both toxin-induced and genetically determined PD that have provided significant insight for understanding this disease. We also discuss the validity, benefits, and limitations of representative models.http://dx.doi.org/10.4061/2011/951709 |
| spellingShingle | Shin Hisahara Shun Shimohama Toxin-Induced and Genetic Animal Models of Parkinson's Disease Parkinson's Disease |
| title | Toxin-Induced and Genetic Animal Models of Parkinson's Disease |
| title_full | Toxin-Induced and Genetic Animal Models of Parkinson's Disease |
| title_fullStr | Toxin-Induced and Genetic Animal Models of Parkinson's Disease |
| title_full_unstemmed | Toxin-Induced and Genetic Animal Models of Parkinson's Disease |
| title_short | Toxin-Induced and Genetic Animal Models of Parkinson's Disease |
| title_sort | toxin induced and genetic animal models of parkinson s disease |
| url | http://dx.doi.org/10.4061/2011/951709 |
| work_keys_str_mv | AT shinhisahara toxininducedandgeneticanimalmodelsofparkinsonsdisease AT shunshimohama toxininducedandgeneticanimalmodelsofparkinsonsdisease |