Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature
Abstract Primary diffuse leptomeningeal melanomatosis (PDLM) is a rare and malignant form of melanoma, with an incidence of one in ten million. It most commonly occurs in the fourth decade of life and is even rarer in pediatric populations. Due to its nonspecific clinical presentation, it is often m...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | Egyptian Journal of Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41984-025-00423-8 |
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| author | P. V. Sudharsan Jeena Joseph Krishna Prabhu Raju Geeta Chacko |
| author_facet | P. V. Sudharsan Jeena Joseph Krishna Prabhu Raju Geeta Chacko |
| author_sort | P. V. Sudharsan |
| collection | DOAJ |
| description | Abstract Primary diffuse leptomeningeal melanomatosis (PDLM) is a rare and malignant form of melanoma, with an incidence of one in ten million. It most commonly occurs in the fourth decade of life and is even rarer in pediatric populations. Due to its nonspecific clinical presentation, it is often misdiagnosed as tuberculous meningitis or hemorrhage. The pre-operative diagnosis of PDLM prior to surgery is highly challenging and is usually confirmed through biopsy, as cutaneous lesions are not commonly present. We present the case of a 7-year-old boy who exhibited symptoms of raised intracranial pressure and fever, which mimicked an infective etiology but was ultimately diagnosed with primary diffuse leptomeningeal melanomatosis, a histological surprise. |
| format | Article |
| id | doaj-art-9145b6da01dc4154b32ddd9b4e5bf525 |
| institution | DOAJ |
| issn | 2520-8225 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Neurosurgery |
| spelling | doaj-art-9145b6da01dc4154b32ddd9b4e5bf5252025-08-20T03:22:08ZengSpringerOpenEgyptian Journal of Neurosurgery2520-82252025-05-014011410.1186/s41984-025-00423-8Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literatureP. V. Sudharsan0Jeena Joseph1Krishna Prabhu Raju2Geeta Chacko3Department of Neurological Sciences, Christian Medical CollegeDepartment of Neurological Sciences, Christian Medical CollegeDepartment of Neurological Sciences, Christian Medical CollegeDepartment of Pathology, Christian Medical CollegeAbstract Primary diffuse leptomeningeal melanomatosis (PDLM) is a rare and malignant form of melanoma, with an incidence of one in ten million. It most commonly occurs in the fourth decade of life and is even rarer in pediatric populations. Due to its nonspecific clinical presentation, it is often misdiagnosed as tuberculous meningitis or hemorrhage. The pre-operative diagnosis of PDLM prior to surgery is highly challenging and is usually confirmed through biopsy, as cutaneous lesions are not commonly present. We present the case of a 7-year-old boy who exhibited symptoms of raised intracranial pressure and fever, which mimicked an infective etiology but was ultimately diagnosed with primary diffuse leptomeningeal melanomatosis, a histological surprise.https://doi.org/10.1186/s41984-025-00423-8MelanosisPediatricDiffuseLeptomeningealMeningitis |
| spellingShingle | P. V. Sudharsan Jeena Joseph Krishna Prabhu Raju Geeta Chacko Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature Egyptian Journal of Neurosurgery Melanosis Pediatric Diffuse Leptomeningeal Meningitis |
| title | Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature |
| title_full | Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature |
| title_fullStr | Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature |
| title_full_unstemmed | Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature |
| title_short | Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature |
| title_sort | primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis case report and review of literature |
| topic | Melanosis Pediatric Diffuse Leptomeningeal Meningitis |
| url | https://doi.org/10.1186/s41984-025-00423-8 |
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