Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report
Brolucizumab a humanized single-chain antibody fragment targeting VEGF-A is approved for neovascular age-related macular degeneration nAMD and is being studied for other retinal conditions including polypoidal choroidal vasculopathy PCV. This case report presents a 79-year-old I...
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| Format: | Article |
| Language: | English |
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Rajiv Gandhi University of Health Sciences
2025-01-01
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| Series: | RGUHS Journal of Medical Sciences |
| Online Access: | https://journalgrid.com/view/article/rjms/12434377 |
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| author | Mohan S Kalpana Badami Shilpa Y D Hemalata B C |
| author_facet | Mohan S Kalpana Badami Shilpa Y D Hemalata B C |
| author_sort | Mohan S |
| collection | DOAJ |
| description |
Brolucizumab a humanized single-chain antibody fragment targeting VEGF-A is approved for neovascular age-related macular degeneration nAMD and is being studied for other retinal conditions including polypoidal choroidal vasculopathy PCV. This case report presents a 79-year-old Indian male with idiopathic PCV in the right eye characterized by diminished vision and a large serous pigment epithelial detachment PED 1092 mum. He was treated with a pro re nata PRN regimen of intravitreal Brolucizumab 6 mg0.05 ml. After the first injection PED reduced to 68 mum but later resurfaced 423 mum requiring a second injection. Subsequent follow-ups showed fluctuations in fluid levels necessitating a third injection after which complete resolution was observed. This case highlights Brolucizumabrsquos effectiveness in managing serous PED in IPCV with repeated administration improving long-term fluid resolution. |
| format | Article |
| id | doaj-art-9142699db934422eaeb277064c79f5e1 |
| institution | OA Journals |
| issn | 2231-1947 2581-7248 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Rajiv Gandhi University of Health Sciences |
| record_format | Article |
| series | RGUHS Journal of Medical Sciences |
| spelling | doaj-art-9142699db934422eaeb277064c79f5e12025-08-20T02:11:22ZengRajiv Gandhi University of Health SciencesRGUHS Journal of Medical Sciences2231-19472581-72482025-01-0115210.26463/rjms.15_2_2Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case ReportMohan SKalpana BadamiShilpa Y DHemalata B C Brolucizumab a humanized single-chain antibody fragment targeting VEGF-A is approved for neovascular age-related macular degeneration nAMD and is being studied for other retinal conditions including polypoidal choroidal vasculopathy PCV. This case report presents a 79-year-old Indian male with idiopathic PCV in the right eye characterized by diminished vision and a large serous pigment epithelial detachment PED 1092 mum. He was treated with a pro re nata PRN regimen of intravitreal Brolucizumab 6 mg0.05 ml. After the first injection PED reduced to 68 mum but later resurfaced 423 mum requiring a second injection. Subsequent follow-ups showed fluctuations in fluid levels necessitating a third injection after which complete resolution was observed. This case highlights Brolucizumabrsquos effectiveness in managing serous PED in IPCV with repeated administration improving long-term fluid resolution.https://journalgrid.com/view/article/rjms/12434377 |
| spellingShingle | Mohan S Kalpana Badami Shilpa Y D Hemalata B C Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report RGUHS Journal of Medical Sciences |
| title | Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report |
| title_full | Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report |
| title_fullStr | Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report |
| title_full_unstemmed | Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report |
| title_short | Brolucizumab Monotherapy in Idiopathic Polypoidal Choroidal Vasculopathy:A Case Report |
| title_sort | brolucizumab monotherapy in idiopathic polypoidal choroidal vasculopathy a case report |
| url | https://journalgrid.com/view/article/rjms/12434377 |
| work_keys_str_mv | AT mohans brolucizumabmonotherapyinidiopathicpolypoidalchoroidalvasculopathyacasereport AT kalpanabadami brolucizumabmonotherapyinidiopathicpolypoidalchoroidalvasculopathyacasereport AT shilpayd brolucizumabmonotherapyinidiopathicpolypoidalchoroidalvasculopathyacasereport AT hemalatabc brolucizumabmonotherapyinidiopathicpolypoidalchoroidalvasculopathyacasereport |