Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study
Objective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case–control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within t...
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MDPI AG
2025-02-01
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| author | Aikaterini Kyriakopoulou Kyriakos Samikos Aikaterini Kanavaki Efthymia Alexopoulou Maria Argyropoulou Theodora Psaltopoulou Christina Kanaka-Gantenbein Argyrios Dinopoulos Melpomene Giorgi Anastasia Antoniadou Iliani Filippa Nikolaos Siafakas Stylianos Serghiou Vassiliki Papaevangelou |
| author_facet | Aikaterini Kyriakopoulou Kyriakos Samikos Aikaterini Kanavaki Efthymia Alexopoulou Maria Argyropoulou Theodora Psaltopoulou Christina Kanaka-Gantenbein Argyrios Dinopoulos Melpomene Giorgi Anastasia Antoniadou Iliani Filippa Nikolaos Siafakas Stylianos Serghiou Vassiliki Papaevangelou |
| author_sort | Aikaterini Kyriakopoulou |
| collection | DOAJ |
| description | Objective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case–control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected. Main outcome measure: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided <i>p</i>-values were computed using the likelihood ratio test. Results: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV. Conclusions: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV’s pathophysiological mechanisms. |
| format | Article |
| id | doaj-art-913d273d8a6c4a95854e2b0d11054f87 |
| institution | DOAJ |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-913d273d8a6c4a95854e2b0d11054f872025-08-20T02:44:41ZengMDPI AGChildren2227-90672025-02-0112222310.3390/children12020223Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control StudyAikaterini Kyriakopoulou0Kyriakos Samikos1Aikaterini Kanavaki2Efthymia Alexopoulou3Maria Argyropoulou4Theodora Psaltopoulou5Christina Kanaka-Gantenbein6Argyrios Dinopoulos7Melpomene Giorgi8Anastasia Antoniadou9Iliani Filippa10Nikolaos Siafakas11Stylianos Serghiou12Vassiliki Papaevangelou13Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, GreeceIaso Maternity Hospital, 151 23 Athens, GreeceIaso Maternity Hospital, 151 23 Athens, Greece2nd Department of Radiology, General University Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, GreeceDepartment of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 455 00 Ioannina, GreeceDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, GreeceDiabetes Center, Division of Endocrinology, Diabetes, and Metabolism, First Department of Pediatrics, Agia Sophia Children’s Hospital, National and Kapodistrian University of Athens, 115 27 Athens, GreeceThird Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, GreeceThird Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, GreeceFourth Department of Medicine, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, GreeceIaso Maternity Hospital, 151 23 Athens, GreeceClinical Microbiology Laboratory, Attikon General University Hospital, 124 62 Athens, GreeceProlaio, Inc., Chicago, IL 60606, USAThird Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, GreeceObjective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case–control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected. Main outcome measure: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided <i>p</i>-values were computed using the likelihood ratio test. Results: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV. Conclusions: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV’s pathophysiological mechanisms.https://www.mdpi.com/2227-9067/12/2/223LSVrisk factorsfoetalneonatalcerebral abnormalitiesCMV |
| spellingShingle | Aikaterini Kyriakopoulou Kyriakos Samikos Aikaterini Kanavaki Efthymia Alexopoulou Maria Argyropoulou Theodora Psaltopoulou Christina Kanaka-Gantenbein Argyrios Dinopoulos Melpomene Giorgi Anastasia Antoniadou Iliani Filippa Nikolaos Siafakas Stylianos Serghiou Vassiliki Papaevangelou Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study Children LSV risk factors foetal neonatal cerebral abnormalities CMV |
| title | Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study |
| title_full | Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study |
| title_fullStr | Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study |
| title_full_unstemmed | Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study |
| title_short | Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study |
| title_sort | clinical associations with lenticulostriatal vasculopathy lsv at birth a case control study |
| topic | LSV risk factors foetal neonatal cerebral abnormalities CMV |
| url | https://www.mdpi.com/2227-9067/12/2/223 |
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