Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis
Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/263625 |
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| author | Seung Min Jung Kyoung Woon Kim Chul-Woo Yang Sung-Hwan Park Ji Hyeon Ju |
| author_facet | Seung Min Jung Kyoung Woon Kim Chul-Woo Yang Sung-Hwan Park Ji Hyeon Ju |
| author_sort | Seung Min Jung |
| collection | DOAJ |
| description | Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease of disrupted bone homeostasis. The bone loss and joint destruction are mediated by immunological insults by proinflammatory cytokines and various immune cells. The connection between bone and immunity has been intensely studied and comprises the emerging field of osteoimmunology. Osteoimmunology is an interdisciplinary science investigating the interplay between the skeletal and the immune systems. The main contributors in osteoimmunology are the bone effector cells, such as osteoclasts or osteoblasts, and the immune cells, particularly lymphocytes and monocytes. Physiologically, osteoclasts originate from immune cells, and immune cells regulate osteoblasts and vice versa. Pathological conditions such as RA might affect these interactions, thereby altering bone homeostasis, resulting in the unfavorable outcome of bone destruction. In this review, we describe the osteoclastogenic roles of the proinflammatory cytokines and immune cells that are important in the pathophysiology of RA. |
| format | Article |
| id | doaj-art-913b944535204271ad716fa0a4e386ea |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-913b944535204271ad716fa0a4e386ea2025-08-20T03:37:05ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/263625263625Cytokine-Mediated Bone Destruction in Rheumatoid ArthritisSeung Min Jung0Kyoung Woon Kim1Chul-Woo Yang2Sung-Hwan Park3Ji Hyeon Ju4Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero, Seocho-Gu, Seoul 137-701, Republic of KoreaConvergent Research Consortium for Immunologic Disease, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaConvergent Research Consortium for Immunologic Disease, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero, Seocho-Gu, Seoul 137-701, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero, Seocho-Gu, Seoul 137-701, Republic of KoreaBone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease of disrupted bone homeostasis. The bone loss and joint destruction are mediated by immunological insults by proinflammatory cytokines and various immune cells. The connection between bone and immunity has been intensely studied and comprises the emerging field of osteoimmunology. Osteoimmunology is an interdisciplinary science investigating the interplay between the skeletal and the immune systems. The main contributors in osteoimmunology are the bone effector cells, such as osteoclasts or osteoblasts, and the immune cells, particularly lymphocytes and monocytes. Physiologically, osteoclasts originate from immune cells, and immune cells regulate osteoblasts and vice versa. Pathological conditions such as RA might affect these interactions, thereby altering bone homeostasis, resulting in the unfavorable outcome of bone destruction. In this review, we describe the osteoclastogenic roles of the proinflammatory cytokines and immune cells that are important in the pathophysiology of RA.http://dx.doi.org/10.1155/2014/263625 |
| spellingShingle | Seung Min Jung Kyoung Woon Kim Chul-Woo Yang Sung-Hwan Park Ji Hyeon Ju Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis Journal of Immunology Research |
| title | Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis |
| title_full | Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis |
| title_fullStr | Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis |
| title_full_unstemmed | Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis |
| title_short | Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis |
| title_sort | cytokine mediated bone destruction in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2014/263625 |
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