IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression

IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression

BackgroundOur previous research highlighted the potential role of immunoglobulin G4 (IgG4) in mediating immunosuppression within the tumor microenvironment (TME). Tertiary lymphoid structures (TLS) in the TME have important immune-related functions. This study aims to analyze the distribution charac...

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Bibliographic Details
Main Authors: Hui Wang, Jirui Li, Yinghai Wang, Yang Chen, Weifeng Zhang, Xinyan Pan, Chanjuan Su, Ziteng Li, Li Wang, Jiang Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin G4
tertiary lymphoid structure
tumor microenvironment
macrophage polarization
interleukin-10
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497783/full
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