Integrated proteogenomic characterization of localized prostate cancer identifies biological insights and subtype-specific therapeutic strategies

Abstract Localized prostate cancer (PCa) is highly variable in their response to therapies. Although a fraction of this heterogeneity can be explained by clinical factors or genomic and transcriptomic profiling, the proteomic-based profiling of aggressive PCa remains poorly understood. Here, we prof...

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Bibliographic Details
Main Authors: Wei Ou, Xin-Xin Zhang, Bin Li, Ying Tuo, Ren-Xuan Lin, Peng-Fei Liu, Jian-Ping Guo, Hio-Cheng Un, Ming-Hao Li, Jia-Hao Lei, Xiao-Jing Gao, Fu-Fu Zheng, Ling-Wu Chen, Ling-Li Long, Zong-Ren Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58569-w
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