Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis
IntroductionThe study aimed to investigate the diagnostic and prognostic value of serum S100A8/9 levels with sHLHa, a high-mortality multiorgan inflammatory syndrome with no reliable clinical biomarkers, where calreticulin’s role is unclear.MethodsThis was a study of 67 newly diagnosed sHLHa patient...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1607352/full |
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| author | Ziwei Fang Xin Gao Limin Duan Jujuan Wang Tian Tian Ji Xu Yongqian Shu Guangli Yin Hongxia Qiu |
| author_facet | Ziwei Fang Xin Gao Limin Duan Jujuan Wang Tian Tian Ji Xu Yongqian Shu Guangli Yin Hongxia Qiu |
| author_sort | Ziwei Fang |
| collection | DOAJ |
| description | IntroductionThe study aimed to investigate the diagnostic and prognostic value of serum S100A8/9 levels with sHLHa, a high-mortality multiorgan inflammatory syndrome with no reliable clinical biomarkers, where calreticulin’s role is unclear.MethodsThis was a study of 67 newly diagnosed sHLHa patients. 48 patients met criteria and were analyzed. ELISA detected S100A8/9 levels in patients and controls. The optimal classification threshold for S100A8/9 was determined to be 2.44 µg/mL by restricted cubic spline (RCS) curve analysis. Patients were categorized. Correlations, diagnostic efficacy, survival differences, and prognosis impacts were analyzed.ResultsSerum S100A8/9 levels in sHLHa patients were greater than in healthy controls. Various analyses showed its diagnostic and prognostic value. ANC<1.0 × 109/L and high S100A8/9 expression group were independent risk factors for poor prognosis in patients with sHLHa. It’s correlated with liver function indicators and HScore.DiscussionThis study evaluates S100A8/9 in sHLHa diagnosis and prognosis. S100A8/9 levels are useful for differentiating patients, providing etiologic and survival info. They show a nonlinear positive correlation with survival and a threshold effect. Serum S100A8/9 levels offer potential biomarkers, and further studies are needed. |
| format | Article |
| id | doaj-art-9123c17b9b41438bbced5ebd5a8afbb8 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-9123c17b9b41438bbced5ebd5a8afbb82025-08-20T03:50:48ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-07-011210.3389/fmolb.2025.16073521607352Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosisZiwei Fang0Xin Gao1Limin Duan2Jujuan Wang3Tian Tian4Ji Xu5Yongqian Shu6Guangli Yin7Hongxia Qiu8Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, ChinaIntroductionThe study aimed to investigate the diagnostic and prognostic value of serum S100A8/9 levels with sHLHa, a high-mortality multiorgan inflammatory syndrome with no reliable clinical biomarkers, where calreticulin’s role is unclear.MethodsThis was a study of 67 newly diagnosed sHLHa patients. 48 patients met criteria and were analyzed. ELISA detected S100A8/9 levels in patients and controls. The optimal classification threshold for S100A8/9 was determined to be 2.44 µg/mL by restricted cubic spline (RCS) curve analysis. Patients were categorized. Correlations, diagnostic efficacy, survival differences, and prognosis impacts were analyzed.ResultsSerum S100A8/9 levels in sHLHa patients were greater than in healthy controls. Various analyses showed its diagnostic and prognostic value. ANC<1.0 × 109/L and high S100A8/9 expression group were independent risk factors for poor prognosis in patients with sHLHa. It’s correlated with liver function indicators and HScore.DiscussionThis study evaluates S100A8/9 in sHLHa diagnosis and prognosis. S100A8/9 levels are useful for differentiating patients, providing etiologic and survival info. They show a nonlinear positive correlation with survival and a threshold effect. Serum S100A8/9 levels offer potential biomarkers, and further studies are needed.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1607352/fullphagocytic lymphohistiocytosisS100A8/9RCSdiagnosisprognosis |
| spellingShingle | Ziwei Fang Xin Gao Limin Duan Jujuan Wang Tian Tian Ji Xu Yongqian Shu Guangli Yin Hongxia Qiu Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis Frontiers in Molecular Biosciences phagocytic lymphohistiocytosis S100A8/9 RCS diagnosis prognosis |
| title | Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis |
| title_full | Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis |
| title_fullStr | Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis |
| title_full_unstemmed | Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis |
| title_short | Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis |
| title_sort | expression and clinical significance of s100a8 9 in adults with secondary phagocytic lymphohistiocytosis |
| topic | phagocytic lymphohistiocytosis S100A8/9 RCS diagnosis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1607352/full |
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