Proteomic analysis of tumor cell nuclear expulsion reveals significant cell adhesion and RNA binding programs in extracellular chromatin

Proteomic analysis of tumor cell nuclear expulsion reveals significant cell adhesion and RNA binding programs in extracellular chromatin

Abstract Understanding mechanisms of cancer cell death and the resulting effect on disease progression is crucial in cancer biology and the insight will likely offer better options for therapeutic treatment. Nuclear expulsion occurs in apoptotic cancer cells in a peptidylarginine deiminase 4 (Padi4)...

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Bibliographic Details
Main Authors: Justin M. Gray, Woo Yong Park, Ronald J. Holewinski, Thorkell Andresson, Carmelo Carmona-Rivera, Mariana J. Kaplan, Li Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Cancer
Apoptosis
Chromatin
Proteomics
Nuclear expulsion
Online Access:https://doi.org/10.1038/s41598-025-11807-z
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