Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium

Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium

Abstract Intestinal epithelial-derived IL-18 is critical for homeostatic intestinal barrier function and is secreted through Gasdermin D (GSDMD) pores. Inflammasome activation is a prerequisite for both IL-18 maturation and GSDMD pore formation. However, GSDMD pores also cause pyroptotic cell death,...

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Main Authors: J. K. Bruce, L. Y. Li, Y. Tang, E. Forster, N. J. Winsor, P. Y. Bi, C. Krustev, S. Keely, J. E. Lee, J. R. Rohde, H. Y. Gaisano, D. J. Philpott, S. E. Girardin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08183-9
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