Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function
ABSTRACT Background Fibroblast growth factors(FGF)19 subclass related to endocrine metabolism, including FGF19, FGF21, and FGF23, which is associated with cognition. Age can affect its secretion and has been identified as a significant risk factor for cognitive decline. Consequently, age may moderat...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70784 |
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| author | Ligang Shan Ying Tao Jiubo Fan Yuyu Zhou Danyang Zhao Yanlong Liu Xiaoli Han Suriyakala Perumal Chandran Fan Wang |
| author_facet | Ligang Shan Ying Tao Jiubo Fan Yuyu Zhou Danyang Zhao Yanlong Liu Xiaoli Han Suriyakala Perumal Chandran Fan Wang |
| author_sort | Ligang Shan |
| collection | DOAJ |
| description | ABSTRACT Background Fibroblast growth factors(FGF)19 subclass related to endocrine metabolism, including FGF19, FGF21, and FGF23, which is associated with cognition. Age can affect its secretion and has been identified as a significant risk factor for cognitive decline. Consequently, age may moderate the impact of the FGF19 subclass on cognitive function. This study aimed to investigate the association among the FGF19 subclass in cerebrospinal fluid (CSF), cognition, and age and further explore the moderating effects of age on cognitive changes related to the FGF19 subclass. Methods In this cross‐sectional study, participants were stratified into two groups based on age, namely the ≤34 year old (n = 128) and >34 year old (n = 63) groups, and CSF FGF19 subclass levels were measured. Cognition was assessed using the Montreal Cognitive Assessment Scores. Results Age may play a moderating effect in the relationship between CSF FGF21 and cognition (R2 = 0.12, β = ‐0.32, p = 0.003). In individuals aged >34 years old, a negative correlation was observed between serum TG levels and MoCA scores (r = ‐0.31, p = .041). Contrastingly, no correlation was noted between CSF FGF19 and CSF FGF23 levels with MoCA scores in both groups, respectively (all p > 0.05). Conclusions This is the first study to report that age plays a moderating effect in the relationship between CSF FGF21 and cognition. Moreover, higher CSF FGF21 levels have a protective effect on cognition in individuals aged ≤34 years old. However, individuals aged>34 years old can improve cognition via alternative strategies. |
| format | Article |
| id | doaj-art-911ddc1cdb0442bfbee8ebee4313835d |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-911ddc1cdb0442bfbee8ebee4313835d2025-08-20T04:02:28ZengWileyBrain and Behavior2162-32792025-08-01158n/an/a10.1002/brb3.70784Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive FunctionLigang Shan0Ying Tao1Jiubo Fan2Yuyu Zhou3Danyang Zhao4Yanlong Liu5Xiaoli Han6Suriyakala Perumal Chandran7Fan Wang8Department of Anesthesiology The Second Affiliated Hospital of Xiamen Medical College Xiamen ChinaMedical Neurobiology Lab Inner Mongolia Medical University Hohhot ChinaXiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science Xiangyang ChinaMedical Neurobiology Lab Inner Mongolia Medical University Hohhot ChinaMedical Neurobiology Lab Inner Mongolia Medical University Hohhot ChinaSchool of Mental Health Wenzhou Medical University Wenzhou ChinaClinical Nutrition Department Friendship Hospital of Urumqi in Xinjiang Urumqi ChinaFaculty of Medicine Lincoln University College Petaling Jaya MalaysiaBeijing Hui‐Long‐Guan Hospital Peking University Beijing ChinaABSTRACT Background Fibroblast growth factors(FGF)19 subclass related to endocrine metabolism, including FGF19, FGF21, and FGF23, which is associated with cognition. Age can affect its secretion and has been identified as a significant risk factor for cognitive decline. Consequently, age may moderate the impact of the FGF19 subclass on cognitive function. This study aimed to investigate the association among the FGF19 subclass in cerebrospinal fluid (CSF), cognition, and age and further explore the moderating effects of age on cognitive changes related to the FGF19 subclass. Methods In this cross‐sectional study, participants were stratified into two groups based on age, namely the ≤34 year old (n = 128) and >34 year old (n = 63) groups, and CSF FGF19 subclass levels were measured. Cognition was assessed using the Montreal Cognitive Assessment Scores. Results Age may play a moderating effect in the relationship between CSF FGF21 and cognition (R2 = 0.12, β = ‐0.32, p = 0.003). In individuals aged >34 years old, a negative correlation was observed between serum TG levels and MoCA scores (r = ‐0.31, p = .041). Contrastingly, no correlation was noted between CSF FGF19 and CSF FGF23 levels with MoCA scores in both groups, respectively (all p > 0.05). Conclusions This is the first study to report that age plays a moderating effect in the relationship between CSF FGF21 and cognition. Moreover, higher CSF FGF21 levels have a protective effect on cognition in individuals aged ≤34 years old. However, individuals aged>34 years old can improve cognition via alternative strategies.https://doi.org/10.1002/brb3.70784agecerebrospinal fluidcognitionfibroblast growth factor 21moderation |
| spellingShingle | Ligang Shan Ying Tao Jiubo Fan Yuyu Zhou Danyang Zhao Yanlong Liu Xiaoli Han Suriyakala Perumal Chandran Fan Wang Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function Brain and Behavior age cerebrospinal fluid cognition fibroblast growth factor 21 moderation |
| title | Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function |
| title_full | Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function |
| title_fullStr | Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function |
| title_full_unstemmed | Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function |
| title_short | Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function |
| title_sort | age a moderating effect on cerebrospinal fluid fibroblast growth factor 21 and cognitive function |
| topic | age cerebrospinal fluid cognition fibroblast growth factor 21 moderation |
| url | https://doi.org/10.1002/brb3.70784 |
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