Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects
Cancer remains a primary cause of mortality, with over 18.1 million new cases and 9.6 million deaths globally in 2018. Chemotherapy, which utilizes a spectrum of cytotoxic drugs targeting the rapidly dividing cancer cells, is a predominant treatment modality. However, the tendency of chemotherapeuti...
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| Format: | Article |
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MDPI AG
2025-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/3/350 |
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| author | Shouyan Xiang Yubei Li Shah Nawaz Khan Weixin Zhang Gaoyang Yuan Jiahua Cui |
| author_facet | Shouyan Xiang Yubei Li Shah Nawaz Khan Weixin Zhang Gaoyang Yuan Jiahua Cui |
| author_sort | Shouyan Xiang |
| collection | DOAJ |
| description | Cancer remains a primary cause of mortality, with over 18.1 million new cases and 9.6 million deaths globally in 2018. Chemotherapy, which utilizes a spectrum of cytotoxic drugs targeting the rapidly dividing cancer cells, is a predominant treatment modality. However, the tendency of chemotherapeutics to induce drug resistance and exhibit non-specific cytotoxicity necessitates the development of new anticancer agents with heightened efficacy and minimized toxicity. In recent years, the discovery of safe and effective antibacterial/antiviral agents has also been a hot spot in medicinal chemistry. This paper comprehensively reviews the synthesis, anticancer/antibacterial/antiviral activity, and structure–activity relationships of natural 1,4-naphthoquinones and their derivatives. It highlights their potential as efficient and low-toxicity antitumor and anti-infectious drug candidates. |
| format | Article |
| id | doaj-art-91177c3c559546fd98bd5e6b38dda683 |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-91177c3c559546fd98bd5e6b38dda6832025-08-20T01:48:49ZengMDPI AGPharmaceuticals1424-82472025-02-0118335010.3390/ph18030350Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future ProspectsShouyan Xiang0Yubei Li1Shah Nawaz Khan2Weixin Zhang3Gaoyang Yuan4Jiahua Cui5School of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, ChinaCancer remains a primary cause of mortality, with over 18.1 million new cases and 9.6 million deaths globally in 2018. Chemotherapy, which utilizes a spectrum of cytotoxic drugs targeting the rapidly dividing cancer cells, is a predominant treatment modality. However, the tendency of chemotherapeutics to induce drug resistance and exhibit non-specific cytotoxicity necessitates the development of new anticancer agents with heightened efficacy and minimized toxicity. In recent years, the discovery of safe and effective antibacterial/antiviral agents has also been a hot spot in medicinal chemistry. This paper comprehensively reviews the synthesis, anticancer/antibacterial/antiviral activity, and structure–activity relationships of natural 1,4-naphthoquinones and their derivatives. It highlights their potential as efficient and low-toxicity antitumor and anti-infectious drug candidates.https://www.mdpi.com/1424-8247/18/3/3501,4-naphthoquinonesanticancerantimicrobialantiviralstructure–activity relationshipsnatural products |
| spellingShingle | Shouyan Xiang Yubei Li Shah Nawaz Khan Weixin Zhang Gaoyang Yuan Jiahua Cui Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects Pharmaceuticals 1,4-naphthoquinones anticancer antimicrobial antiviral structure–activity relationships natural products |
| title | Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects |
| title_full | Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects |
| title_fullStr | Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects |
| title_full_unstemmed | Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects |
| title_short | Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects |
| title_sort | exploiting the anticancer antimicrobial and antiviral potential of naphthoquinone derivatives recent advances and future prospects |
| topic | 1,4-naphthoquinones anticancer antimicrobial antiviral structure–activity relationships natural products |
| url | https://www.mdpi.com/1424-8247/18/3/350 |
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