High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition
Feeding sheep with high-concentrate diet (HCD) to shorten production cycle is a well-developed feeding strategy to increase lamb production. Here, metabolomics were performed to explore the mechanism that HCD changes lamb nutrition composition. Differential metabolites were enriched in primary bile...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Food Chemistry: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590157524007594 |
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| author | Kaizhi Zheng Liangyong Guo Yang Cao Yuyang Yin Hui Gao Xiaowei Zhang Junfang Jiang Jinbing Li Xin Huang Kui Li Sangang He |
| author_facet | Kaizhi Zheng Liangyong Guo Yang Cao Yuyang Yin Hui Gao Xiaowei Zhang Junfang Jiang Jinbing Li Xin Huang Kui Li Sangang He |
| author_sort | Kaizhi Zheng |
| collection | DOAJ |
| description | Feeding sheep with high-concentrate diet (HCD) to shorten production cycle is a well-developed feeding strategy to increase lamb production. Here, metabolomics were performed to explore the mechanism that HCD changes lamb nutrition composition. Differential metabolites were enriched in primary bile acid biosynthesis. Significantly higher content of bile acids including taurodeoxycholic acid sodium salt (TDCA), taurochenodeoxycholic acid sodium salt (TCDCA) and taurocholic acid (TCA) was observed in lamb of HCD, while the content of lithocholic acid (LCA), cholic acid (CA), chenodeoxycholic acid (CDCA) and Chenodeoxycholic acid-3-beta-D-glucuronide (CDCA-3Gln) were higher in the controls. Furthermore, a significantly decreased content of fatty acids was observed in lamb of HCD group. Finally, primary skeletal cells treated with CA or TCA showed a significant decrease in contents of fatty acids, while TCA showed a stronger effect in decreasing fatty acid contents. Collectively, we suggest that HCD decreases lamb fatty acid contents by regulating bile acid composition. |
| format | Article |
| id | doaj-art-91155689f8b94c8fb4999411e51ffe66 |
| institution | OA Journals |
| issn | 2590-1575 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry: X |
| spelling | doaj-art-91155689f8b94c8fb4999411e51ffe662025-08-20T02:38:15ZengElsevierFood Chemistry: X2590-15752024-12-012410187110.1016/j.fochx.2024.101871High-concentrate diet decreases lamb fatty acid contents by regulating bile acid compositionKaizhi Zheng0Liangyong Guo1Yang Cao2Yuyang Yin3Hui Gao4Xiaowei Zhang5Junfang Jiang6Jinbing Li7Xin Huang8Kui Li9Sangang He10Institute of Animal Husbandry and Veterinary, Zhejiang, Academy of Agricultural Sciences, Hangzhou 310021, ChinaHuzhou Academy of Agricultural Sciences, Huzhou 313000, ChinaInstitute of Animal Husbandry and Veterinary, Zhejiang, Academy of Agricultural Sciences, Hangzhou 310021, ChinaHuzhou Academy of Agricultural Sciences, Huzhou 313000, ChinaAnimal Husbandry Technology Promotion and Breeding Livestock and Poultry Monitoring Station of Zhejiang Province, Hangzhou 310000, ChinaAnimal Husbandry Technology Promotion and Breeding Livestock and Poultry Monitoring Station of Zhejiang Province, Hangzhou 310000, ChinaInstitute of Animal Husbandry and Veterinary, Zhejiang, Academy of Agricultural Sciences, Hangzhou 310021, ChinaShangyu District Animal Husbandry and Veterinary Technology Promotion Center, Shaoxing 312300, ChinaInstitute of Animal Husbandry and Veterinary, Zhejiang, Academy of Agricultural Sciences, Hangzhou 310021, China; Corresponding authors.Animal Husbandry Technology Promotion and Breeding Livestock and Poultry Monitoring Station of Zhejiang Province, Hangzhou 310000, China; Corresponding authors.Institute of Animal Husbandry and Veterinary, Zhejiang, Academy of Agricultural Sciences, Hangzhou 310021, China; Corresponding authors.Feeding sheep with high-concentrate diet (HCD) to shorten production cycle is a well-developed feeding strategy to increase lamb production. Here, metabolomics were performed to explore the mechanism that HCD changes lamb nutrition composition. Differential metabolites were enriched in primary bile acid biosynthesis. Significantly higher content of bile acids including taurodeoxycholic acid sodium salt (TDCA), taurochenodeoxycholic acid sodium salt (TCDCA) and taurocholic acid (TCA) was observed in lamb of HCD, while the content of lithocholic acid (LCA), cholic acid (CA), chenodeoxycholic acid (CDCA) and Chenodeoxycholic acid-3-beta-D-glucuronide (CDCA-3Gln) were higher in the controls. Furthermore, a significantly decreased content of fatty acids was observed in lamb of HCD group. Finally, primary skeletal cells treated with CA or TCA showed a significant decrease in contents of fatty acids, while TCA showed a stronger effect in decreasing fatty acid contents. Collectively, we suggest that HCD decreases lamb fatty acid contents by regulating bile acid composition.http://www.sciencedirect.com/science/article/pii/S2590157524007594High-concentrate dietMetabolomicsLambBile acidFatty acid |
| spellingShingle | Kaizhi Zheng Liangyong Guo Yang Cao Yuyang Yin Hui Gao Xiaowei Zhang Junfang Jiang Jinbing Li Xin Huang Kui Li Sangang He High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition Food Chemistry: X High-concentrate diet Metabolomics Lamb Bile acid Fatty acid |
| title | High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition |
| title_full | High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition |
| title_fullStr | High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition |
| title_full_unstemmed | High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition |
| title_short | High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition |
| title_sort | high concentrate diet decreases lamb fatty acid contents by regulating bile acid composition |
| topic | High-concentrate diet Metabolomics Lamb Bile acid Fatty acid |
| url | http://www.sciencedirect.com/science/article/pii/S2590157524007594 |
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