Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis

Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis

Background: Cryptococcal meningitis causes an estimated 112,000 global deaths annually. Genomic and phenotypic features of the infecting strain of Cryptococcus spp. have been studied extensively. Population-level pharmacokinetic variability is well documented in these patient cohorts. The relative c...

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Main Authors: Dr Katharine Stott, Mr Jason Mohabir, Miss Kate Bowers, Assistant Professor Jennifer Tenor, Associate Professor Dena Tofaletti, Dr Jennifer Unsworth, Ms Ana Jimenez-Valverde, Mr Ajisa Ahmadu, Dr Melanie Moyo, Mrs Ebbie Gondwe, Mrs Wezi Chimang'anga, Mr Madalitso Chasweka, Dr David Lawrence, Professor Joseph Jarvis, Professor Tom Harrison, Professor William Hope, Professor David Lalloo, Professor Henry Mwandumba, Professor John Perfect, Professor Christina Cuomo
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:International Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971224007148
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