The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors
objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors . Methodology: This study is conducted in the Department of Pathology, Faculty...
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| Language: | English |
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University of Kufa, Faculty of Nursing
2014-12-01
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| Series: | Kufa Journal for Nursing Sciences |
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| Online Access: | https://journal.uokufa.edu.iq/index.php/kjns/article/view/2767 |
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| author | Kaswer Musa Al-Turaihi Roaa hameed Al-Waidh |
| author_facet | Kaswer Musa Al-Turaihi Roaa hameed Al-Waidh |
| author_sort | Kaswer Musa Al-Turaihi |
| collection | DOAJ |
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objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors .
Methodology: This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January - October 2013. A total of 50 patients with neuroendocrine tumors from different locations. their ages ranging between 22-80 years with a mean age of 48.3 years. Two step Envision TM flex method was employed for immunohistochemical detection of ki67 antigen (MIB -1) and Chromogranin A .
Results: Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance, from 50 patients 44 (88%) cases was positive for Chromoranin A expression , there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value >0.05)
Conclusion: Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade .
Recommendation: We advise to use Chromogranin A immunohistochemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy .
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| format | Article |
| id | doaj-art-9108bc2db7b24ca89ac922aabd0ab66b |
| institution | OA Journals |
| issn | 2223-4055 2521-8638 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | University of Kufa, Faculty of Nursing |
| record_format | Article |
| series | Kufa Journal for Nursing Sciences |
| spelling | doaj-art-9108bc2db7b24ca89ac922aabd0ab66b2025-08-20T02:27:04ZengUniversity of Kufa, Faculty of NursingKufa Journal for Nursing Sciences2223-40552521-86382014-12-014310.36321/kjns.vi20143.2767The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine TumorsKaswer Musa Al-Turaihi0Roaa hameed Al-Waidh1University of KufaUniversity of Kufa objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors . Methodology: This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January - October 2013. A total of 50 patients with neuroendocrine tumors from different locations. their ages ranging between 22-80 years with a mean age of 48.3 years. Two step Envision TM flex method was employed for immunohistochemical detection of ki67 antigen (MIB -1) and Chromogranin A . Results: Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance, from 50 patients 44 (88%) cases was positive for Chromoranin A expression , there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value >0.05) Conclusion: Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade . Recommendation: We advise to use Chromogranin A immunohistochemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy . https://journal.uokufa.edu.iq/index.php/kjns/article/view/2767neuroendocrine tumor chromogranin A |
| spellingShingle | Kaswer Musa Al-Turaihi Roaa hameed Al-Waidh The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors Kufa Journal for Nursing Sciences neuroendocrine tumor chromogranin A |
| title | The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors |
| title_full | The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors |
| title_fullStr | The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors |
| title_full_unstemmed | The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors |
| title_short | The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors |
| title_sort | application of immunohistochemical markers for diagnosis classification and grading of neuroendocrine tumors |
| topic | neuroendocrine tumor chromogranin A |
| url | https://journal.uokufa.edu.iq/index.php/kjns/article/view/2767 |
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