The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors
objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors . Methodology: This study is conducted in the Department of Pathology, Faculty...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Kufa, Faculty of Nursing
2014-12-01
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| Series: | Kufa Journal for Nursing Sciences |
| Subjects: | |
| Online Access: | https://journal.uokufa.edu.iq/index.php/kjns/article/view/2767 |
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| Summary: | objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors .
Methodology: This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January - October 2013. A total of 50 patients with neuroendocrine tumors from different locations. their ages ranging between 22-80 years with a mean age of 48.3 years. Two step Envision TM flex method was employed for immunohistochemical detection of ki67 antigen (MIB -1) and Chromogranin A .
Results: Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance, from 50 patients 44 (88%) cases was positive for Chromoranin A expression , there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value >0.05)
Conclusion: Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade .
Recommendation: We advise to use Chromogranin A immunohistochemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy .
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| ISSN: | 2223-4055 2521-8638 |