Neutrophil extracellular traps are associated with poor response to neoadjuvant therapy and poor survival in pediatric osteosarcoma

Neutrophil extracellular traps are associated with poor response to neoadjuvant therapy and poor survival in pediatric osteosarcoma

PurposeOsteosarcoma (OS), the most common primary bone malignancy in childhood poses a therapeutic challenge despite extensive research. Neutrophil extracellular traps (NETs) play a role in the tumor microenvironment (TME) in a variety of cancers, but their role in OS has not been characterized.Expe...

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Bibliographic Details
Main Authors: Szilvia Baron, Yoav Binenbaum, Ronny Maman, Victoria Fidel, Anna Shusterman, Dmitry Vaisman, Osnat Sher, Michal Manisterski, Rachel Shukrun, Claudia Rössig, Ronit Elhasid
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma
tumor microenvironment (TME)
neutrophil
neutrophil extracellular traps (NETs)
T cell
chemotherapy resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1472716/full
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