A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy
A healthy 45-year-old Japanese female developed right pleural effusion, ascites, and a pelvic mass. Bilateral salpingo-oophorectomy resolved the pleural effusion and ascites. Histopathological examination of the ovaries showed bilateral Krukenberg tumors with signet-ring cell carcinoma (SRCC). Exten...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/797429 |
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| author | Yoshiaki Nakamura Ayako Hiramatsu Takafumi Koyama Yu Oyama Ayuko Tanaka Koichi Honma |
| author_facet | Yoshiaki Nakamura Ayako Hiramatsu Takafumi Koyama Yu Oyama Ayuko Tanaka Koichi Honma |
| author_sort | Yoshiaki Nakamura |
| collection | DOAJ |
| description | A healthy 45-year-old Japanese female developed right pleural effusion, ascites, and a pelvic mass. Bilateral salpingo-oophorectomy resolved the pleural effusion and ascites. Histopathological examination of the ovaries showed bilateral Krukenberg tumors with signet-ring cell carcinoma (SRCC). Extensive testing including upper and lower gastrointestinal endoscopy and whole-body imaging did not detect the primary lesion. Six months after bilateral salpingo-oophorectomy, the patient developed multiple osteoblastic bone lesions in the spine, pelvis, and femurs. A biopsy of the bone marrow showed SRCC. We administered four cycles of S-1 and cisplatin, resulting in the shrinkage of osteoblastic lesions; she remained stable for a year. Then, she developed disseminated intravascular coagulation with disease progression in the bones. Although she was treated with paclitaxel, the disseminated intravascular coagulation progressed, and she died in a month. During the autopsy, microscopic examination revealed four foci of intramucosal gastric SRCC and healthy macroscopic gastric mucosa. |
| format | Article |
| id | doaj-art-90fe2956cd6e4e87b6d537df26f3fa22 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-90fe2956cd6e4e87b6d537df26f3fa222025-02-03T05:46:01ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/797429797429A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an AutopsyYoshiaki Nakamura0Ayako Hiramatsu1Takafumi Koyama2Yu Oyama3Ayuko Tanaka4Koichi Honma5Department of Oncology, Kameda Medical Center, Kamogawa, Chiba 296-8602, JapanDepartment of Oncology, Kameda Medical Center, Kamogawa, Chiba 296-8602, JapanDepartment of Oncology, Kameda Medical Center, Kamogawa, Chiba 296-8602, JapanDepartment of Oncology, Kameda Medical Center, Kamogawa, Chiba 296-8602, JapanDepartment of Gynecology, Kameda Medical Center, Kamogawa, Chiba 296-8602, JapanDepartment of Anatomic and Diagnostic Pathology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, JapanA healthy 45-year-old Japanese female developed right pleural effusion, ascites, and a pelvic mass. Bilateral salpingo-oophorectomy resolved the pleural effusion and ascites. Histopathological examination of the ovaries showed bilateral Krukenberg tumors with signet-ring cell carcinoma (SRCC). Extensive testing including upper and lower gastrointestinal endoscopy and whole-body imaging did not detect the primary lesion. Six months after bilateral salpingo-oophorectomy, the patient developed multiple osteoblastic bone lesions in the spine, pelvis, and femurs. A biopsy of the bone marrow showed SRCC. We administered four cycles of S-1 and cisplatin, resulting in the shrinkage of osteoblastic lesions; she remained stable for a year. Then, she developed disseminated intravascular coagulation with disease progression in the bones. Although she was treated with paclitaxel, the disseminated intravascular coagulation progressed, and she died in a month. During the autopsy, microscopic examination revealed four foci of intramucosal gastric SRCC and healthy macroscopic gastric mucosa.http://dx.doi.org/10.1155/2014/797429 |
| spellingShingle | Yoshiaki Nakamura Ayako Hiramatsu Takafumi Koyama Yu Oyama Ayuko Tanaka Koichi Honma A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy Case Reports in Oncological Medicine |
| title | A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy |
| title_full | A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy |
| title_fullStr | A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy |
| title_full_unstemmed | A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy |
| title_short | A Krukenberg Tumor from an Occult Intramucosal Gastric Carcinoma Identified during an Autopsy |
| title_sort | krukenberg tumor from an occult intramucosal gastric carcinoma identified during an autopsy |
| url | http://dx.doi.org/10.1155/2014/797429 |
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