Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in such cases. Monitoring chimerism makes it possi...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2022-12-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/710 |
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| author | D. S. Dubnyak N. V. Risinskaya M. Yu. Drokov A. B. Sudarikov |
| author_facet | D. S. Dubnyak N. V. Risinskaya M. Yu. Drokov A. B. Sudarikov |
| author_sort | D. S. Dubnyak |
| collection | DOAJ |
| description | Allogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in such cases. Monitoring chimerism makes it possible both to assess the graft acceptance, and also potentially predict the risk of developing primary/secondary graft failure, relapse, and graft-versus-host disease.The purpose of this review is to summarize the main concepts associated with chimerism after allogeneic hematopoietic stem cell transplantation; consideration of the need to study chimerism in various cell populations, as well as the relationship between chimerism and the development of various immunological complications. |
| format | Article |
| id | doaj-art-90fcdb28c02c4b8f8fda00eee2198a27 |
| institution | DOAJ |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-90fcdb28c02c4b8f8fda00eee2198a272025-08-20T03:18:19ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092022-12-0114448849910.23873/2074-0506-2022-14-4-488-499544Monitoring of chimerism after allogeneic hematopoietic stem cell transplantationD. S. Dubnyak0N. V. Risinskaya1M. Yu. Drokov2A. B. Sudarikov3National Medical Research Center for HematologyNational Medical Research Center for HematologyNational Medical Research Center for HematologyNational Medical Research Center for HematologyAllogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in such cases. Monitoring chimerism makes it possible both to assess the graft acceptance, and also potentially predict the risk of developing primary/secondary graft failure, relapse, and graft-versus-host disease.The purpose of this review is to summarize the main concepts associated with chimerism after allogeneic hematopoietic stem cell transplantation; consideration of the need to study chimerism in various cell populations, as well as the relationship between chimerism and the development of various immunological complications.https://www.jtransplantologiya.ru/jour/article/view/710allogeneic hematopoietic stem celltransplantationсhimerism after transplantation |
| spellingShingle | D. S. Dubnyak N. V. Risinskaya M. Yu. Drokov A. B. Sudarikov Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation Трансплантология (Москва) allogeneic hematopoietic stem cell transplantation сhimerism after transplantation |
| title | Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation |
| title_full | Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation |
| title_fullStr | Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation |
| title_full_unstemmed | Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation |
| title_short | Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation |
| title_sort | monitoring of chimerism after allogeneic hematopoietic stem cell transplantation |
| topic | allogeneic hematopoietic stem cell transplantation сhimerism after transplantation |
| url | https://www.jtransplantologiya.ru/jour/article/view/710 |
| work_keys_str_mv | AT dsdubnyak monitoringofchimerismafterallogeneichematopoieticstemcelltransplantation AT nvrisinskaya monitoringofchimerismafterallogeneichematopoieticstemcelltransplantation AT myudrokov monitoringofchimerismafterallogeneichematopoieticstemcelltransplantation AT absudarikov monitoringofchimerismafterallogeneichematopoieticstemcelltransplantation |