A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets

A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets

Abstract This study aims to investigate the expression of seven cancer testis antigens (MAGE-A1, MAGE-A4, MAGE-A10, MAGE-A11, PRAME, NY-ESO-1 and KK-LC-1) in pan squamous cell carcinoma and their prognostic value, thus assessing the potential of these CTAs as immunotherapeutic targets. The protein e...

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Bibliographic Details
Main Authors: Lin Li, Xin Zhang, Jiayao Yan, Jingyi Guo, Fangcen Liu, Xiao Wei, Qin Liu, Kongcheng Wang, Baorui Liu
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Cancer testis antigens
Head and neck squamous cell carcinoma
Lung squamous cell carcinoma
Esophageal squamous cell carcinoma
Immunotherapy
PD-L1
Online Access:https://doi.org/10.1007/s12672-025-01804-z
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