Dental biofilm serves as an ecological reservoir of acidogenic pathobionts in head and neck cancer patients with radiotherapy-related caries

Dental biofilm serves as an ecological reservoir of acidogenic pathobionts in head and neck cancer patients with radiotherapy-related caries

ABSTRACT Radiotherapy-related caries (RRC) is an aggressive and debilitating oral toxicity that affects half of the patients who undergo radiotherapy for head and neck cancer. However, the etiology of RRC is not fully established, and there are no clinically validated methods for preventing it. To g...

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Bibliographic Details
Main Authors: Julia S. Bruno, Vitor Heidrich, Felipe C. F. Restini, Tatiana M. M. T. Alves, Wanessa Miranda-Silva, Franciele H. Knebel, Elisangela M. Cóser, Lilian T. Inoue, Paula F. Asprino, Anamaria A. Camargo, Eduardo R. Fregnani
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSphere
Subjects:
oral microbiome
radiotherapy
toxicity
biofilm
dental caries
supportive care
Online Access:https://journals.asm.org/doi/10.1128/msphere.00257-25
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