Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents
Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation. Edible bird’s nest (EBN) is a glycoprotein (sialylated mucin glycopeptides) found to be beneficial against neurodegenerative diseases. Antioxidative, anti-inflammatory, and anti-apoptotic...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002403 |
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| author | Weiyi Chu Chia Wei Phan Seng Joe Lim Abdul Salam Babji |
| author_facet | Weiyi Chu Chia Wei Phan Seng Joe Lim Abdul Salam Babji |
| author_sort | Weiyi Chu |
| collection | DOAJ |
| description | Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation. Edible bird’s nest (EBN) is a glycoprotein (sialylated mucin glycopeptides) found to be beneficial against neurodegenerative diseases. Antioxidative, anti-inflammatory, and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo models. Functional effects of EBN are often linked to its great number of antioxidants and anti-inflammatory glycopeptides. Bioactive compounds in EBN, especially sialic acid, add value to neurotrophic potential of EBN and contribute to neuronal repair and protection. Various studies reporting the neuroprotective effects of EBN, their molecular mechanisms, and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN. |
| format | Article |
| id | doaj-art-90f9182a870d4daaa73f80c3ea6da3f3 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-90f9182a870d4daaa73f80c3ea6da3f32025-02-03T07:06:24ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-0112410081019Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituentsWeiyi Chu0Chia Wei Phan1Seng Joe Lim2Abdul Salam Babji3Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia; Clinical Investigation Centre, University Malaya Medical Centre, Lembah Pantai Kuala Lumpur 59100, Malaysia; Mushroom Research Centre, Universiti Malaya, Kuala Lumpur 50603, Malaysia; Corresponding author at: Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, Malaysia; Innovation Centre for Confectionery Technology (MANIS), Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, MalaysiaDepartment of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, Malaysia; Innovation Centre for Confectionery Technology (MANIS), Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor 43600, MalaysiaNeurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation. Edible bird’s nest (EBN) is a glycoprotein (sialylated mucin glycopeptides) found to be beneficial against neurodegenerative diseases. Antioxidative, anti-inflammatory, and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo models. Functional effects of EBN are often linked to its great number of antioxidants and anti-inflammatory glycopeptides. Bioactive compounds in EBN, especially sialic acid, add value to neurotrophic potential of EBN and contribute to neuronal repair and protection. Various studies reporting the neuroprotective effects of EBN, their molecular mechanisms, and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.http://www.sciencedirect.com/science/article/pii/S2213453022002403AntioxidantCompositionEdible bird nestNeurodegenerative diseaseNeuroprotectionSialylated mucin glycopeptide |
| spellingShingle | Weiyi Chu Chia Wei Phan Seng Joe Lim Abdul Salam Babji Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents Food Science and Human Wellness Antioxidant Composition Edible bird nest Neurodegenerative disease Neuroprotection Sialylated mucin glycopeptide |
| title | Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents |
| title_full | Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents |
| title_fullStr | Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents |
| title_full_unstemmed | Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents |
| title_short | Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents |
| title_sort | insights on the molecular mechanism of neuroprotection exerted by edible bird s nest and its bioactive constituents |
| topic | Antioxidant Composition Edible bird nest Neurodegenerative disease Neuroprotection Sialylated mucin glycopeptide |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002403 |
| work_keys_str_mv | AT weiyichu insightsonthemolecularmechanismofneuroprotectionexertedbyediblebirdsnestanditsbioactiveconstituents AT chiaweiphan insightsonthemolecularmechanismofneuroprotectionexertedbyediblebirdsnestanditsbioactiveconstituents AT sengjoelim insightsonthemolecularmechanismofneuroprotectionexertedbyediblebirdsnestanditsbioactiveconstituents AT abdulsalambabji insightsonthemolecularmechanismofneuroprotectionexertedbyediblebirdsnestanditsbioactiveconstituents |