Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis
Abstract Objective To assess the efficacy and safety of stem cell therapy in human studies for diabetic peripheral neuropathy (DPN). Methods A comprehensive literature review was performed across multiple databases, including Ovid MEDLINE ALL, Embase via Ovid SP, Scopus, Web of Science Core Collecti...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04033-3 |
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| author | Seyed Danial Alizadeh Shima Jahani Mohammad Rezaei Zadeh Rukerd Reza Tabrizi Rasoul Masoomi Seyedeh Zahra Banihashemian Mahgol Sadat Hassan Zadeh Tabatabaei Zahra Ghodsi Ahmad Pour-Rashidi James Harrop Vafa Rahimi-Movaghar |
| author_facet | Seyed Danial Alizadeh Shima Jahani Mohammad Rezaei Zadeh Rukerd Reza Tabrizi Rasoul Masoomi Seyedeh Zahra Banihashemian Mahgol Sadat Hassan Zadeh Tabatabaei Zahra Ghodsi Ahmad Pour-Rashidi James Harrop Vafa Rahimi-Movaghar |
| author_sort | Seyed Danial Alizadeh |
| collection | DOAJ |
| description | Abstract Objective To assess the efficacy and safety of stem cell therapy in human studies for diabetic peripheral neuropathy (DPN). Methods A comprehensive literature review was performed across multiple databases, including Ovid MEDLINE ALL, Embase via Ovid SP, Scopus, Web of Science Core Collection, and Cochrane CENTRAL, up to January 31, 2024. Keywords and controlled vocabularies related to diabetic neuropathy and stem cell therapy were used. Inclusion criteria encompassed all controlled trials examining stem cell therapy for DPN, excluding animal or in vitro studies, review papers, conference abstracts, and editor letters. Data extraction and risk of bias assessment were independently performed by multiple reviewers using standardized tools. Results Out of 5431 initial entries, seven were included. Stem cell therapies included bone marrow-derived mononuclear cells and umbilical cord-derived mesenchymal stem cells, administered mainly via intramuscular transplantation. Meta-analysis indicated significant improvements in motor nerve conduction velocity (weighted mean differences (WMD): 2.2, 95% CI 1.6–2.8) and sensory nerve conduction velocity (WMD: 1.9, 95% CI 1.1–2.6). Vibration perception threshold and Toronto Clinical Scoring System scores decreased significantly (WMD: − 2.9, 95% CI − 4.0, − 1.8, and WMD: − 3.6, 95% CI − 5.0, − 2.2, respectively). Sensitivity analysis and subgroup analysis confirmed the robustness and specificity of these findings. The complications were pain and swelling at the injection sites, which disappeared in a few days. Conclusion Stem cell therapy shows significant promise in improving clinical outcomes for DPN, with evident benefits in nerve conduction and sensory parameters. Further research is needed to consolidate these findings and optimize therapeutic protocols. |
| format | Article |
| id | doaj-art-90f705d5e69341589ee56bb57f167e4d |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-90f705d5e69341589ee56bb57f167e4d2025-08-20T02:33:00ZengBMCStem Cell Research & Therapy1757-65122024-11-0115111610.1186/s13287-024-04033-3Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysisSeyed Danial Alizadeh0Shima Jahani1Mohammad Rezaei Zadeh Rukerd2Reza Tabrizi3Rasoul Masoomi4Seyedeh Zahra Banihashemian5Mahgol Sadat Hassan Zadeh Tabatabaei6Zahra Ghodsi7Ahmad Pour-Rashidi8James Harrop9Vafa Rahimi-Movaghar10Sina Trauma and Surgery Research Center, Tehran University of Medical SciencesMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical SciencesDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRNoncommunicable Diseases Research Center, Fasa University of Medical ScienceSina Trauma and Surgery Research Center, Tehran University of Medical SciencesStudent Research Committee, Faculty of Medicine, Semnan University of Medical SciencesSina Trauma and Surgery Research Center, Tehran University of Medical SciencesSina Trauma and Surgery Research Center, Tehran University of Medical SciencesDepartment of Neurosurgery, Sina Hospital, Tehran University of Medical SciencesDepartment of Neurosurgery, Thomas Jefferson UniversitySina Trauma and Surgery Research Center, Tehran University of Medical SciencesAbstract Objective To assess the efficacy and safety of stem cell therapy in human studies for diabetic peripheral neuropathy (DPN). Methods A comprehensive literature review was performed across multiple databases, including Ovid MEDLINE ALL, Embase via Ovid SP, Scopus, Web of Science Core Collection, and Cochrane CENTRAL, up to January 31, 2024. Keywords and controlled vocabularies related to diabetic neuropathy and stem cell therapy were used. Inclusion criteria encompassed all controlled trials examining stem cell therapy for DPN, excluding animal or in vitro studies, review papers, conference abstracts, and editor letters. Data extraction and risk of bias assessment were independently performed by multiple reviewers using standardized tools. Results Out of 5431 initial entries, seven were included. Stem cell therapies included bone marrow-derived mononuclear cells and umbilical cord-derived mesenchymal stem cells, administered mainly via intramuscular transplantation. Meta-analysis indicated significant improvements in motor nerve conduction velocity (weighted mean differences (WMD): 2.2, 95% CI 1.6–2.8) and sensory nerve conduction velocity (WMD: 1.9, 95% CI 1.1–2.6). Vibration perception threshold and Toronto Clinical Scoring System scores decreased significantly (WMD: − 2.9, 95% CI − 4.0, − 1.8, and WMD: − 3.6, 95% CI − 5.0, − 2.2, respectively). Sensitivity analysis and subgroup analysis confirmed the robustness and specificity of these findings. The complications were pain and swelling at the injection sites, which disappeared in a few days. Conclusion Stem cell therapy shows significant promise in improving clinical outcomes for DPN, with evident benefits in nerve conduction and sensory parameters. Further research is needed to consolidate these findings and optimize therapeutic protocols.https://doi.org/10.1186/s13287-024-04033-3Diabetic neuropathyAdult stem cellUmbilical cord blood stem cell transplantationBone marrow cell transplantationMeta-analysis |
| spellingShingle | Seyed Danial Alizadeh Shima Jahani Mohammad Rezaei Zadeh Rukerd Reza Tabrizi Rasoul Masoomi Seyedeh Zahra Banihashemian Mahgol Sadat Hassan Zadeh Tabatabaei Zahra Ghodsi Ahmad Pour-Rashidi James Harrop Vafa Rahimi-Movaghar Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis Stem Cell Research & Therapy Diabetic neuropathy Adult stem cell Umbilical cord blood stem cell transplantation Bone marrow cell transplantation Meta-analysis |
| title | Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis |
| title_full | Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis |
| title_fullStr | Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis |
| title_full_unstemmed | Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis |
| title_short | Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis |
| title_sort | human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy a systematic review and meta analysis |
| topic | Diabetic neuropathy Adult stem cell Umbilical cord blood stem cell transplantation Bone marrow cell transplantation Meta-analysis |
| url | https://doi.org/10.1186/s13287-024-04033-3 |
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