An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases

An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases

ABSTRACT Influenza, as well as other respiratory viruses, can trigger local and systemic inflammation resulting in an overall “cytokine storm” that produces serious outcomes such as acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). We hypothesized that gene therapy platforms cou...

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Bibliographic Details
Main Authors: Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
TLR4
MD-2
HMGB1
Box A
influenza
LPS
Online Access:https://journals.asm.org/doi/10.1128/mbio.03387-24
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