Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections
Background. We aimed to analyze the levels and associations of SH2 domain-containing protein 1A (SH2D1A), immunoglobulins and T lymphocyte (TL) subsets in children with Epstein-Barr virus (EBV) infections. Methods. Sixty children with EBV infections admitted from January 2019 to Januar...
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| Language: | English |
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Hacettepe University Institute of Child Health
2023-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/67 |
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| _version_ | 1850240584607858688 |
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| author | Penghong Xu Jinsu Zhou Yue Xiao Hongjun Miao |
| author_facet | Penghong Xu Jinsu Zhou Yue Xiao Hongjun Miao |
| author_sort | Penghong Xu |
| collection | DOAJ |
| description |
Background. We aimed to analyze the levels and associations of SH2 domain-containing protein 1A (SH2D1A), immunoglobulins and T lymphocyte (TL) subsets in children with Epstein-Barr virus (EBV) infections.
Methods. Sixty children with EBV infections admitted from January 2019 to January 2022 were selected, including 29 cases of infectious mononucleosis (IM group) and 31 cases of chronic active EBV infections (CAEBV group). Another 42 healthy children undergoing physical examination in the same period were selected as a control group. Their changes in SH2D1A, immunoglobulins and TL subsets (CD3+, CD4+ and CD8+) were compared.
Results. The levels of CD3+, CD4+ and CD8+ in the IM group were higher than those of the control group (P < 0.05), while they were lower in the CAEBV group than those of the control and IM groups (P < 0.05). The levels of SH2D1A, signaling lymphocyte activation molecule (SLAM) and SLAM-associated protein (SAP) were significantly higher in the IM group than those in the control and CAEBV groups (P < 0.05). The CAEBV group had decreased protein expressions of SLAM and SAP compared with those of the IM group. SH2D1A was positively correlated with immunoglobulin A, immunoglobulin G and TL subsets (CD3+, CD4+ and CD8+) (P < 0.05).
Conclusions. Detecting SH2D1A, immunoglobulins and TLs contributes to the diagnosis and differentiation of IM and CAEBV.
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| format | Article |
| id | doaj-art-90f4bee2114f4e98a65997fc434ba343 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-90f4bee2114f4e98a65997fc434ba3432025-08-20T02:00:50ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212023-08-0165410.24953/turkjped.2022.1128Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infectionsPenghong Xu0Jinsu Zhou1Yue Xiao2Hongjun Miao3Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China. Background. We aimed to analyze the levels and associations of SH2 domain-containing protein 1A (SH2D1A), immunoglobulins and T lymphocyte (TL) subsets in children with Epstein-Barr virus (EBV) infections. Methods. Sixty children with EBV infections admitted from January 2019 to January 2022 were selected, including 29 cases of infectious mononucleosis (IM group) and 31 cases of chronic active EBV infections (CAEBV group). Another 42 healthy children undergoing physical examination in the same period were selected as a control group. Their changes in SH2D1A, immunoglobulins and TL subsets (CD3+, CD4+ and CD8+) were compared. Results. The levels of CD3+, CD4+ and CD8+ in the IM group were higher than those of the control group (P < 0.05), while they were lower in the CAEBV group than those of the control and IM groups (P < 0.05). The levels of SH2D1A, signaling lymphocyte activation molecule (SLAM) and SLAM-associated protein (SAP) were significantly higher in the IM group than those in the control and CAEBV groups (P < 0.05). The CAEBV group had decreased protein expressions of SLAM and SAP compared with those of the IM group. SH2D1A was positively correlated with immunoglobulin A, immunoglobulin G and TL subsets (CD3+, CD4+ and CD8+) (P < 0.05). Conclusions. Detecting SH2D1A, immunoglobulins and TLs contributes to the diagnosis and differentiation of IM and CAEBV. https://turkjpediatr.org/article/view/67Epstein-Barr virusSH2 domain-containing protein 1ASLAM-associated proteinT lymphocyte subsetsclinical diagnosisimmunoglobulins |
| spellingShingle | Penghong Xu Jinsu Zhou Yue Xiao Hongjun Miao Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections The Turkish Journal of Pediatrics Epstein-Barr virus SH2 domain-containing protein 1A SLAM-associated protein T lymphocyte subsets clinical diagnosis immunoglobulins |
| title | Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections |
| title_full | Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections |
| title_fullStr | Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections |
| title_full_unstemmed | Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections |
| title_short | Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections |
| title_sort | association of sh2 domain containing protein 1a immunoglobulins and t lymphocyte subsets with epstein barr virus infections |
| topic | Epstein-Barr virus SH2 domain-containing protein 1A SLAM-associated protein T lymphocyte subsets clinical diagnosis immunoglobulins |
| url | https://turkjpediatr.org/article/view/67 |
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