Promoting vascular stability through Src inhibition and Tie2 activation: A model-based analysis

Summary: Dysregulated angiogenesis signaling leads to pathological vascular growth and leakage, and is a hallmark of many diseases including cancer and ocular diseases. In peripheral arterial disease, the concomitant increase in vascular permeability presents significant challenges in therapeutic ef...

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Bibliographic Details
Main Authors: Yu Zhang, Christopher D. Kontos, Brian H. Annex, Aleksander S. Popel
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008867
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