A Brief Chronicle of Antibody Research and Technological Advances
This review briefly traces the historical development of antibody research and related technologies. The path from early perceptions of immunity to the emergence of modern immunotherapy has been marked by pivotal discoveries and technological advances. Early insights into immunity led to the develop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Antibodies |
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| Online Access: | https://www.mdpi.com/2073-4468/13/4/90 |
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| _version_ | 1850042385531142144 |
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| author | Kazutaka Araki Ryota Maeda |
| author_facet | Kazutaka Araki Ryota Maeda |
| author_sort | Kazutaka Araki |
| collection | DOAJ |
| description | This review briefly traces the historical development of antibody research and related technologies. The path from early perceptions of immunity to the emergence of modern immunotherapy has been marked by pivotal discoveries and technological advances. Early insights into immunity led to the development of vaccination and serotherapy. The elucidation of antibody structure and function paved the way for monoclonal antibody technology and its application in diagnosis and therapy. Breakthroughs in genetic engineering have enabled the production of humanized antibodies and the advances in Fc engineering, thereby increasing therapeutic efficacy. The discovery of immune checkpoints and cytokines revolutionized the treatment of cancer and autoimmune diseases. The field continues to evolve rapidly with the advent of antibody–drug conjugates, bispecific antibodies, and CAR T-cell therapies. As we face global health challenges, antibody research remains at the forefront of medical innovation and offers promising solutions for the future. |
| format | Article |
| id | doaj-art-90e3b3fcd0ff4eecbc6ae60a0456fecc |
| institution | DOAJ |
| issn | 2073-4468 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj-art-90e3b3fcd0ff4eecbc6ae60a0456fecc2025-08-20T02:55:35ZengMDPI AGAntibodies2073-44682024-11-011349010.3390/antib13040090A Brief Chronicle of Antibody Research and Technological AdvancesKazutaka Araki0Ryota Maeda1AIST-UTokyo Advanced Operando-Measurement Technology Open Innovation Laboratory (Operando-Oil), National Institute of Advanced Industrial Science and Technology (AIST), 6-2-3 Kashiwanoha, Chiba 277-0882, JapanCOGNANO Inc., 64-101 Kamitakano Higashiyama, Sakyo-ku, Kyoto 601-1255, JapanThis review briefly traces the historical development of antibody research and related technologies. The path from early perceptions of immunity to the emergence of modern immunotherapy has been marked by pivotal discoveries and technological advances. Early insights into immunity led to the development of vaccination and serotherapy. The elucidation of antibody structure and function paved the way for monoclonal antibody technology and its application in diagnosis and therapy. Breakthroughs in genetic engineering have enabled the production of humanized antibodies and the advances in Fc engineering, thereby increasing therapeutic efficacy. The discovery of immune checkpoints and cytokines revolutionized the treatment of cancer and autoimmune diseases. The field continues to evolve rapidly with the advent of antibody–drug conjugates, bispecific antibodies, and CAR T-cell therapies. As we face global health challenges, antibody research remains at the forefront of medical innovation and offers promising solutions for the future.https://www.mdpi.com/2073-4468/13/4/90antibodyimmunoglobulinimmunology |
| spellingShingle | Kazutaka Araki Ryota Maeda A Brief Chronicle of Antibody Research and Technological Advances Antibodies antibody immunoglobulin immunology |
| title | A Brief Chronicle of Antibody Research and Technological Advances |
| title_full | A Brief Chronicle of Antibody Research and Technological Advances |
| title_fullStr | A Brief Chronicle of Antibody Research and Technological Advances |
| title_full_unstemmed | A Brief Chronicle of Antibody Research and Technological Advances |
| title_short | A Brief Chronicle of Antibody Research and Technological Advances |
| title_sort | brief chronicle of antibody research and technological advances |
| topic | antibody immunoglobulin immunology |
| url | https://www.mdpi.com/2073-4468/13/4/90 |
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