LCZ696 Ameliorates Isoproterenol-Induced Acute Heart Failure in Rats by Activating the Nrf2 Signaling Pathway

LCZ696 Ameliorates Isoproterenol-Induced Acute Heart Failure in Rats by Activating the Nrf2 Signaling Pathway

Objective. LCZ696 (sacubitril/valsartan) is an angiotensin II (Ang II) type 1 receptor-neprilysin inhibitor, with effects of immunosuppression, anti-inflammation, antiapoptosis, and antioxidation. The present study was aimed at determining whether LCZ696 has a protective effect against isoproterenol...

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Bibliographic Details
Main Authors:	Min Hou, Linxin Lu, Xiaobo Wu, Hongxuan Liu
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Applied Bionics and Biomechanics
Online Access:	http://dx.doi.org/10.1155/2022/6077429
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